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ProteomicsAre Mouse Models a surrogate for human disease? A temporal, quantitative and molecular perspective.
It is unclear to what extent Tau molecular pathology in murine models reflect human Tauopathies. Nevertheless, mouse models that overexpress human mutant Tau (P301S and P301L) are widely used in studies of Tauopathies and Alzheimer’s Disease (AD). In this study, we perform an in-depth temporally and...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-03 | PXD033965 | Pride
Are mouse models a surrogate for human disease? a temporal Quantitative and molecular perspective. 
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - angular gyrus
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo sapiens (Human) 
2020-12-04 | PXD020517 | Pride
Alzheimer's disease  post-translational modification  clinical progression  srm  lfq  human tau  protein aggregation  proteopathy 
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - MC1-isolated Tau
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo sapiens (Human) 
2020-12-04 | PXD020482 | Pride
Alzheimer's disease  post-translational modification  clinical progression  srm  lfq  human tau  protein aggregation  proteopathy 
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - high/low molecular weight tau
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo sapiens (Human) 
2020-12-04 | PXD020483 | Pride
Alzheimer's disease  post-translational modification  clinical progression  srm  lfq  human tau  protein aggregation  proteopathy 
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - frontal gyrus
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo sapiens (Human) 
2020-12-04 | PXD020538 | Pride
Alzheimer's disease  post-translational modification  clinical progression  srm  lfq  human tau  protein aggregation  proteopathy 
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - frontal gyrus (sarkosyl soluble)
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo sapiens (Human) 
2020-12-04 | PXD020717 | Pride
Alzheimer's disease  post-translational modification  clinical progression  srm  lfq  human tau  protein aggregation  proteopathy 
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - MC1-isolated Tau
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-18 | MSV000088408 | MassIVE
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - frontal gyrus
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-18 | MSV000088407 | MassIVE
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - angular gyrus
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-18 | MSV000088406 | MassIVE
ProteomicsQuantitative PTM Maps of Human Pathologic Tau Identify Patient Heterogeneity and Define Critical Steps in Alzheimer’s Disease Progression - high/low molecular weight tau
To elucidate the role of Tau isoforms and PTM stoichiometry in Alzheimer’s disease (AD), we generated a high resolution quantitative proteomic map of 88 PTMs on multiple isoforms of Tau isolated from the post-mortem human tissue from 49 AD and 42 control subjects. While Tau PTM maps reveal heterogen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-17 | MSV000088405 | MassIVE
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