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UnknownSlower Walking Speed Is Related to Early Femoral Trochlear Cartilage Degradation After ACL Reconstruction.
Post-traumatic patellofemoral osteoarthritis (OA) is prevalent after anterior cruciate ligament reconstruction (ACLR) and early cartilage degradation may be especially common in the femoral trochlear cartilage. Determining the presence of and factors associated with early femoral trochlear cartilage...
S-EPMC7028512 | biostudies-literature
UnknownThe relation of MRI-detected structural damage in the medial and lateral patellofemoral joint to knee pain: the Multicenter and Framingham Osteoarthritis Studies.

Objective

To examine the relation of cartilage loss and bone marrow lesions (BMLs) in the medial and lateral patellofemoral joint (PFJ) to knee pain.

Methods

We categorized the location of full-thickness cartilage loss and BMLs in the PFJ on knee magnetic resonance imaging (MRIs) from...
S-EPMC4368472 | biostudies-literature
UnknownFDA-Approved Drugs Efavirenz, Tipranavir, and Dasabuvir Inhibit Replication of Multiple Flaviviruses in Vero Cells.
Vector-borne flaviviruses (VBFs) affect human health worldwide, but no approved drugs are available specifically to treat VBF-associated infections. Here, we performed in silico screening of a library of U.S. Food and Drug Administration-approved antiviral drugs for their interaction with Zika virus...
S-EPMC7232190 | biostudies-literature
UnknownIs superolateral Hoffa's fat pad hyperintensity a marker of local patellofemoral joint disease? - The MOST study.

Purpose

To determine the relation of superolateral Hoffa's fat pad (SHFP) hyperintensity to cartilage damage and bone marrow lesions (BMLs) in the patellofemoral joint (PFJ) and tibiofemoral joint (TFJ).

Methods

We used data from the 60 and 84-month study visits from the Multicenter O...
S-EPMC5583732 | biostudies-literature
UnknownChanges in patellofemoral and tibiofemoral joint cartilage damage and bone marrow lesions over 7 years: the Multicenter Osteoarthritis Study.

Objectives

To investigate changes in cartilage damage and bone marrow lesions (BMLs) on MRI in the patellofemoral and tibiofemoral joints (TFJs) over 7 years.

Methods

The Multicenter Osteoarthritis (MOST) Study is a cohort study of persons aged 50-79 years at baseline with or at high ...
S-EPMC4907825 | biostudies-literature
UnknownBreaking the Law of Valgus: the surprising and unexplained prevalence of medial patellofemoral cartilage damage.

Objectives

To compare the prevalence of medial and lateral patellofemoral (PF) cartilage damage in three large osteoarthritis (OA) studies and determine the relationship of this damage to varus, neutral and valgus knee alignment.

Methods

In the Boston OA of the Knee, Framingham OA and...
S-EPMC4011177 | biostudies-literature
UnknownUsing Cumulative Load to Explain How Body Mass Index and Daily Walking Relate to Worsening Knee Cartilage Damage Over Two Years: The MOST Study.

Objective

Knee cartilage damage is often linked to mechanical overloading. However, cartilage requires mechanical load to remain healthy, suggesting that underloading may be detrimental. This study was undertaken to examine knee overloading and underloading by defining cumulative load as the...
S-EPMC8020569 | biostudies-literature
UnknownHeterogeneity of cartilage damage in Kellgren and Lawrence grade 2 and 3 knees: the MOST study.

Objective

Eligibility for clinical trials in osteoarthritis (OA) is usually limited to Kellgren-Lawrence (KL) grades 2 and 3 knees. Our aim was to describe the prevalence and severity of cartilage damage in KL 2 and 3 knees by compartment and articular subregion.

Design

The Multicente...
S-EPMC9433455 | biostudies-literature
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