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GenomicsYAP1 exerts its transcriptional control via TEAD mediated activation of enhancers
YAP is the principle effector of the Hippo signaling pathway; a key regulator of tissue homeostasis whose dysregulation is linked to cancer development. YAP regulation of gene expression is thought to involve the TEAD transcription factor family. Here we show that YAP and TEAD1 binding always co-occ...
ORGANISM(S): Homo sapiens 
2015-08-25 | E-GEOD-61852 | biostudies-arrayexpress
TranscriptomicsTranslocations Activating IRF4 Identify a Subtype of Germinal-Center-Derived B-cell Lymphoma Affecting Predominantly Children and Young Adults
Background: Germinal center B-cell (GCB) lymphomas are common in children and adults. The prognosis strongly depends on age. Subgroups of GCB-lymphomas are characterized by chromosomal translocations affecting immunoglobulin (IG) loci leading to oncogene deregulation. Methods: Novel IG translocation...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-22470 | biostudies-arrayexpress
TranscriptomicsEffect of YAP overexpression on HuCCT1 cholangiocarcinoma cell line transcriptome (YAPS94A)
The YAP pathway in regulating organ size by integrating external signals to control the expression of genes involved in cell proliferation. YAP is known to be involved in tumorigenesis in several tissues, yet its role in cholangiocarcinoma is not established We used microarrays to assess the role of...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-69655 | biostudies-arrayexpress
TranscriptomicsEffect of YAP overexpression on HuCCT1 cholangiocarcinoma cell line transcriptome (YAP overexpression)
The YAP pathway in regulating organ size by integrating external signals to control the expression of genes involved in cell proliferation. YAP is known to be involved in tumorigenesis in several tissues, yet its role in cholangiocarcinoma is not established We used microarrays to assess the role of...
ORGANISM(S): Homo sapiens 
2015-10-27 | E-GEOD-61764 | biostudies-arrayexpress
TranscriptomicsEffect of YAP overexpression on HuCCT1 cholangiocarcinoma cell line transcriptome (shRNA targeting YAP)
The YAP pathway in regulating organ size by integrating external signals to control the expression of genes involved in cell proliferation. YAP is known to be involved in tumorigenesis in several tissues, yet its role in cholangiocarcinoma is not established We used microarrays to assess the role of...
ORGANISM(S): Homo sapiens 
2015-10-27 | E-GEOD-61765 | biostudies-arrayexpress
TranscriptomicsRNA-seq of CN, CN/AML, and CN/AML BAALC KO iPSCs-derived HSPCs
Severe congenital neutropenia (CN) is a pre-leukemia syndrome that, in the majority of patients, is caused by heterogeneous ELANE mutations encoding neutrophil elastase (NE). To study leukemogenesis associated with CN we generated CN and CN/AML patient-specific induced pluripotent stem cells (iPSCs)...
ORGANISM(S): Homo sapiens 
2021-03-08 | E-MTAB-10162 | biostudies-arrayexpress
UnknownStandardization of Imaging Criteria for Detecting Macular Fibrosis in Neovascular Age-Related Macular Degeneration.
Not available
S-EPMC12830330 | biostudies-literature
UnknownMethotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial.
Not available
S-EPMC4486345 | biostudies-literature
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