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MetabolomicsMetabolic characterization of directly reprogrammed renal tubular epithelial cells (iRECs)
Fibroblasts can be directly reprogrammed to induced renal tubular epithelial cells (iRECs) using four transcription factors. These engineered cells may be used for disease modeling, cell replacement therapy or drug and toxicity testing. Direct reprogramming induces drastic changes in the transcripti...
2021-08-20 | MTBLS608 | MetaboLights
TranscriptomicsComparative analysis of macrophage feeder systems reveals distinct behaviors and key transcriptional shifts in chronic lymphocytic leukemia cells via coculture
Bulk RNA-seq analysis of CLL cells cocultured for 5 days with (A) HD-MDMs, (B) NLCs, and (C)THP-1 macrophages compared to CLL cells in monoculture.
ORGANISM(S): Homo sapiens 
2025-09-01 | E-MTAB-15353 | biostudies-arrayexpress
TranscriptomicsEnvironmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease [NimbleGen]
The actions of environmental toxicants and relevant mixtures in promoting the epigenetic transgenerational inheritance of ovarian disease was investigated with the use of a fungicide, a pesticide mixture, a plastic mixture, dioxin and a hydrocarbon mixture. After transient exposure of an F0 gestatin...
ORGANISM(S): Rattus norvegicus 
2014-07-17 | E-GEOD-59277 | biostudies-arrayexpress
TranscriptomicsEffect of YAP overexpression on HuCCT1 cholangiocarcinoma cell line transcriptome (shRNA targeting YAP)
The YAP pathway in regulating organ size by integrating external signals to control the expression of genes involved in cell proliferation. YAP is known to be involved in tumorigenesis in several tissues, yet its role in cholangiocarcinoma is not established We used microarrays to assess the role of...
ORGANISM(S): Homo sapiens 
2015-10-27 | E-GEOD-61765 | biostudies-arrayexpress
TranscriptomicsEnvironmentally induced epigenetic transgenerational inheritance of ovarian disease
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2014-07-17 | E-GEOD-59278 | biostudies-arrayexpress
ProteomicsStromal cells support the survival of human primary chronic lymphocytic leukemia (CLL) cells
In chronic lymphocytic leukemia (CLL), the tumor cells receive survival support from stromal cells through direct cell contact, soluble factors and extracellular vesicles. The tyrosine protein kinase Lyn, is aberrantly expressed in the malignant and stromal cells in CLL tissue. We therefore studied ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-12 | PXD036932 | Pride
Chronic lymphocytic leukemia Extracellular vesicle Lyn kinase Endosialin 
UnknownPhenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways.
Not available
S-EPMC7265573 | biostudies-literature
MetabolomicsNMR based metabolomics study of Y2 receptor activation by neuropeptide Y in the SK-N-BE2 human neuroblastoma cell line
Neuropeptide Y (NPY) and its Y2 receptors (Y2R) play an important role in regulating growth of various tumors and are highly expressed in human neuroblastoma brain tumors. Cell lines derived from neuroblastoma brain tumors provide a good model to study the consequences of NPY activation of Y2R in tu...
2014-10-01 | MTBLS104 | MetaboLights
TranscriptomicsEnvironmental Toxicants Induce Epigenetic Transgenerational Inheritance of Ovarian Disease
The epigenetic transgenerational actions of environmental toxicants and relevant mixtures on ovarian disease was investigated with the use of a fungicide, a pesticide mixture, a plastic mixture, dioxin and a hydrocarbon mixture. After transient exposure of an F0 gestating female rat during embryonic...
ORGANISM(S): Rattus norvegicus 
2012-03-01 | E-GEOD-33423 | biostudies-arrayexpress
TranscriptomicsGene Bionetworks that Regulate Ovarian Primordial Follicle Assembly
Primordial follicle assembly is the process by which ovarian primordial follicles are formed. During follicle assembly oocyte nests break down and a layer of pre-granulosa cells surrounds individual oocytes to form primordial follicles. The pool of primordial follicles formed is the source of oocy...
ORGANISM(S): Rattus norvegicus 
2013-01-15 | E-GEOD-43464 | biostudies-arrayexpress
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