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GenomicsCTCF and CohesinSA-1 Mark Active Promoters and Boundaries of Repressive Chromatin Domains in Primary Human Erythroid Cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-06-27 | E-GEOD-67893 | biostudies-arrayexpress
TranscriptomicsPatterns of histone H3 Lysine 27 monomethylation and erythroid cell-type specific gene expression [expression]
ERYTHROID CELL-TYPE SPECIFIC GENE EXPRESSION Post-translational histone modifications, acting alone or in a context-dependent manner, influence numerous cellular processes via their regulation of gene expression. Monomethylation of histone H3 lysine 27 (K27me1) is a poorly understood histone modific...
ORGANISM(S): Homo sapiens 
2011-12-06 | E-GEOD-32135 | biostudies-arrayexpress
TranscriptomicsRibonomic analysis of human Pum1 in HeLa cells
PUF family proteins are among the best characterized regulatory RNA-binding proteins in non-mammalian species, but relatively little is known about mRNA targets or functions of mammalian PUF proteins. In this study, we used ribonomic analysis to identify and analyze mRNAs associated with ribonucleo...
ORGANISM(S): Homo sapiens 
2008-05-01 | E-GEOD-11301 | biostudies-arrayexpress
TranscriptomicsDynamic gene expression by putative hair-cell progenitors during regeneration in the zebrafish lateral line
Hearing loss is most commonly caused by the destruction of mechanosensory hair cells in the ear. This condition is usually permanent: Despite the presence of putative hair-cell progenitors in the cochlea, hair cells are not naturally replenished in adult mammals. Unlike those of the mammalian ear, t...
ORGANISM(S): Danio rerio 
2014-04-01 | E-GEOD-55853 | biostudies-arrayexpress
TranscriptomicsGene signatures in prostate cancer linked to the Gleason score
The identification of novel oncogenic and druggable targets in patient subgroups with poor prognosis may help to develop corresponding targeted therapy approaches. Microarray data analyses of 59 prostate cancer and 39 benign tissue samples revealed major transcriptional differences. More than 5.000 ...
ORGANISM(S): Homo sapiens 
2012-10-19 | E-GEOD-32571 | biostudies-arrayexpress
TranscriptomicsIdentification of the hypothalamic neuronal populations that derive from Pomc-expressing precursors
Hypothalamic neuronal populations are central regulators of energy homeostasis and reproductive function. However, the ontogeny of these critical hypothalamic neuronal populations is largely unknown. Here, we reveal novel cellular fates of the hypothalamic Pomc-expressing precursors by combining mou...
ORGANISM(S): Mus musculus 
2015-04-16 | E-GEOD-56917 | biostudies-arrayexpress
TranscriptomicsSiomycin A treatment in prostate cancer cell lines PC3 and LNCaP
Siomycin A treatment in prostate cancer cell lines resulted in a concurrent inhibition of specific cell cycle genes and strongly impaired cell viability. Illumina microarray experiments were done using PC3 and LNCaP cell lines treated with 0.5 microM Siomaycin A either 24h or 48h in triplicates.
ORGANISM(S): Homo sapiens 
2012-10-19 | E-GEOD-36531 | biostudies-arrayexpress
TranscriptomicsMELK and UBE2C gene knockdown in prostate cancer cell line PC3
In order to address the putative role of MELK and UBE2C in prostate cancer development and progression, we performed functional analysis upon siRNA-based knockdown, and searched for downstream genes and processes by microarray experiments. RNAi-based inhibition of MELK and UBE2C was efficient in PC3...
ORGANISM(S): Homo sapiens 
2012-10-19 | E-GEOD-32873 | biostudies-arrayexpress
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