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GenomicsChIP-seq experiment in J20 hAPP mice and Pilocarpine-treated mice using deltaFosB antibody against whole-hippocampal lysate
∆FosB epigenetically regulates target gene expression; however, whether ∆FosB targets the same genes when induced by recurrent seizures in different neurological conditions like Alzheimer's disease (AD) is unclear. We performed hippocampal ChIP-sequencing to identify ∆FosB target genes in APP mice, ...
ORGANISM(S): Mus musculus 
2020-04-16 | E-MTAB-8954 | biostudies-arrayexpress
TranscriptomicsRNA-seq experiment in J20 hAPP mice and littermate controls measuring total RNA in lysate of microdissected dentate gyrus
∆FosB epigenetically regulates target gene expression; however, whether ∆FosB targets the same genes when induced by recurrent seizures in different neurological conditions like Alzheimer's disease (AD) is unclear. We performed hippocampal ChIP-sequencing to identify ∆FosB target genes in APP mice, ...
ORGANISM(S): Mus musculus 
2020-04-16 | E-MTAB-8963 | biostudies-arrayexpress
TranscriptomicsNkx6.1 regulates islet beta-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors
Loss of functional beta-cell mass is a hallmark of Type 1 and Type 2 diabetes, and methods for restoring these cells are needed. We have previously reported that overexpression of the homeodomain transcription factor Nkx6.1 in rat pancreatic islets induces beta-cell proliferation and enhances glucos...
ORGANISM(S): Rattus norvegicus 
2014-02-18 | E-GEOD-55077 | biostudies-arrayexpress
TranscriptomicsNr4a1 and Nr4a3 upregulate cell cycle genes upregulated in the Nkx6.1 beta-cell proliferation pathway
Loss of functional beta-cell mass is a hallmark of Type 1 and Type 2 diabetes, and methods for restoring these cells are needed. Nkx6.1 induces beta-cell proliferation, but the pathway by which Nkx6.1 activates beta-cell expansion has not been defined. Here we demonstrate that Nkx6.1 induces express...
ORGANISM(S): Rattus norvegicus 
2014-02-18 | E-GEOD-55078 | biostudies-arrayexpress
UnknownSugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts.
Not available
S-EPMC9945426 | biostudies-literature
UnknownOccurrence of multiple respiratory viruses in wastewater in Queensland, Australia: Potential for community disease surveillance.
Not available
S-EPMC9759456 | biostudies-literature
TranscriptomicsTranscription profiling of human prostate cancer cells, normal epithelial prostatic cells and stroma cells from patients in placebo, selenium, vitamin E or selenium and vitamin E treatment groups
85 radical prostatectomy specimens (where 16 samples are in Placebo group (PL), 15 are in Selenium group (SE), 25 are in Vitamin E group (VE) and 27 are in Vitamin E & Selenium group (VS.Treatment groups: l-selenomethionine, 400 ug + placebo (vitamin E); vitamin E, 400 IU + placebo (l-selenomethion...
ORGANISM(S): Homo sapiens 
2008-07-01 | E-MEXP-1327 | biostudies-arrayexpress
TranscriptomicsSex-specific and lineage-specific alternative splicing in primates
Comparative studies of gene regulation suggest an important role for natural selection in shaping gene expression patterns within and between species. Most of these studies, however, estimated gene expression levels using microarray probes designed to hybridize to only a small proportion of each gen...
ORGANISM(S): Homo sapiens 
2009-12-01 | E-GEOD-17274 | biostudies-arrayexpress
TranscriptomicsComprehensive genomic map of cytosine methylation for wild-type (WT) and Lsh-/- mouse embryonic fibroblasts
DNA methylation is critical for normal development and plays important roles in genome organization and transcriptional regulation. Although DNA methyltransferases have been identified, the factors that establish and contribute to genome-wide methylation patterns remain elusive. Here, we report a hi...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-29394 | biostudies-arrayexpress
TranscriptomicsIndices of Tolerance (IOT): Cross-platform biomarkers that identify kidney transplant tolerance
Being able to identify patients in whom immunological tolerance has been established or is developing would allow an individually tailored approach to post-transplant management of kidney allograft recipients. Ex vivo immunological monitoring was performed on samples from five groups of European ren...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-14655 | biostudies-arrayexpress
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