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ProteomicsObatoclax rescues FUS-ALS phenotypes in iPSC-derived neurons by inducing autophagy
Disruption of protein homeostasis plays an essential role in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). One strategy for restoring protein homeostasis and protecting neurons is to de-repress autophagy by disrupting the inhibitory BECN1/BCL2 complex, which has been sho...
ORGANISM(S): Homo sapiens (Human) 
2023-10-16 | PXD042427 | Pride
Dia Autophagy Ipsc-derived neurons Als Bh3 mimetic Label-free quantitative mass spectrometry Fus 
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