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MetabolomicsCharacteristics of steroid hormones in systemic lupus erythematosus revealed by GC/MS-based metabolic profiling

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a remarkable predominance in female, suggesting that steroid hormones may be involved in the pathogenesis. Herein, more than 70 kinds of steroids in urine were detected by gas chromatography/mass spectrometry (GC/MS) to reve...

2023-07-28 | MTBLS7766 | MetaboLights
MetabolomicsMetabolomics analysis of liver reveals profile disruption in bovines upon steroid treatment
INTRODUCTION: The surveillance of illegal anabolic practices in bovine meat production is necessary to guarantee consumers’ health. Screening strategies based on the recognition of indirect biological effects are considered by the community as promising tools to overcome some limitations of classica...
2018-05-08 | MTBLS436 | MetaboLights
MetabolomicsDysregulation of the 3β-Hydroxysteroid Dehydrogenase Type 2 Enzyme and Steroid Hormone Biosynthesis in Chronic Kidney Disease

Chronic kidney disease (CKD) presents a critical global health challenge, marked by the progressive decline of renal function. This study explores the role of the 3β-hydroxysteroid dehydrogenase type 2 enzyme (HSD3B2) and steroid hormone biosynthesis pathway in CKD pathogenesis and progression. U...

2024-10-10 | MTBLS10715 | MetaboLights
MetabolomicsAnalysis of steroid metabolites in psoriasis.
Not available
ORGANISM(S): Homo sapiens 
ST000298 | MetabolomicsWorkbench
MetabolomicsPredicting and Defining Steroid Resistance in Pediatric Nephrotic Syndrome using Plasma Metabolomics
Not available
ORGANISM(S): Homo sapiens 
ST000939 | MetabolomicsWorkbench
MetabolomicsMetabolic landscape remodeling in dystrophic muscle through glucocorticoid steroid regimens
Not available
ORGANISM(S): Mus musculus 
ST001256 | MetabolomicsWorkbench
TranscriptomicsThe effects of LH ablation/replacement versus steroid ablation/replacement on gene expression in primate corpora lutea
This study was designed to provide a genome-wide analysis of the effects of luteinizing hormone (LH) ablation/replacement versus steroid ablation/replacement on gene expression in the developed corpus luteum (CL) in primates during the menstrual cycle. Naturally cycling, female rhesus monkeys were l...
ORGANISM(S): Macaca mulatta 
2009-01-25 | E-GEOD-12281 | biostudies-arrayexpress
TranscriptomicsComparison of Glomerular Transcriptome Profiles of Adult-Onset Steroid Sensitive Focal Segmental Glomerulosclerosis and Minimal Change Disease
To search for biomarkers to differentiate Adult-Onset Steroid Sensitive focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD). Compared the profiles of glomerular transcriptomes between patients with FSGS and patients with MCD using microarray analysis. This dataset is part of ...
ORGANISM(S): Homo sapiens 
2017-01-04 | E-GEOD-69814 | biostudies-arrayexpress
TranscriptomicsIncreased metallothionein expression reflects steroid resistance in renal allograft recipients.
Steroid-refractory acute rejection is a risk factor for inferior renal allograft outcome. We aimed to gain insight into the mechanisms underlying steroid resistance by identifying novel molecular markers of steroid-refractory acute rejection. Eighty-three kidney transplant recipients (1995-2005), wh...
ORGANISM(S): Homo sapiens 
2013-05-21 | E-GEOD-47097 | biostudies-arrayexpress
TranscriptomicsTranscription array by profiling in WT and SRC-2 null mouse liver
The molecular targets of SRC-2 regulation in the murine liver stimulate fatty acid degradation and glycolytic pathway while fatty acid, cholesterol, and steroid biosynthetic pathways are down-regulated. A genomic approach using microarray analysis was employed to identify the subsets of genes that a...
ORGANISM(S): Mus musculus 
2014-02-14 | E-GEOD-55002 | biostudies-arrayexpress
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