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UnknownPioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis.

Background

Nonalcoholic steatohepatitis is a common liver disease that can progress to cirrhosis. Currently, there is no established treatment for this disease.

Methods

We randomly assigned 247 adults with nonalcoholic steatohepatitis and without diabetes to receive pioglitazone at a ...
S-EPMC2928471 | biostudies-literature
UnknownVitamin E and changes in serum alanine aminotransferase levels in patients with non-alcoholic steatohepatitis.

Background

Non-alcoholic steatohepatitis (NASH) is a common cause of serum alanine aminotransferase (ALT) elevations and chronic liver disease, but it is unclear how well ALT elevations reflect the liver injury.

Aim

To assess how well changes in ALT elevations reflect improvements in ...
S-EPMC3775262 | biostudies-literature
UnknownEffect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial.

Context

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in US children and adolescents and can present with advanced fibrosis or nonalcoholic steatohepatitis (NASH). No treatment has been established.

Objective

To determine whether children with NAFLD...
S-EPMC3110082 | biostudies-literature
UnknownRelationship between adipose tissue insulin resistance and liver histology in nonalcoholic steatohepatitis: a pioglitazone versus vitamin E versus placebo for the treatment of nondiabetic patients with nonalcoholic steatohepatitis trial follow-up study.

Unlabelled

The PIVENS (Pioglitazone versus Vitamin E versus Placebo for the Treatment of Nondiabetic Patients with Nonalcoholic Steatohepatitis [NASH]) trial demonstrated that pioglitazone and vitamin E improved liver histology to varying degrees, but the mechanisms are unknown. We conducted...
S-EPMC3432683 | biostudies-literature
UnknownMutations in the NHEJ component XRCC4 cause primordial dwarfism.
Non-homologous end joining (NHEJ) is a key cellular process ensuring genome integrity. Mutations in several components of the NHEJ pathway have been identified, often associated with severe combined immunodeficiency (SCID), consistent with the requirement for NHEJ during V(D)J recombination to ensur...
S-EPMC4375537 | biostudies-literature
UnknownRelationship between resolution of non-alcoholic steatohepatitis and changes in lipoprotein sub-fractions: a post-hoc analysis of the PIVENS trial.

Background

Dyslipidaemia is frequent in non-alcoholic steatohepatitis (NASH); however, it is unclear if improvement in liver histology is associated with favourable changes in cardiovascular disease (CVD) risk.

Aims

To evaluate the relationship of NASH resolution and lipoprotein subfr...
S-EPMC6461513 | biostudies-literature
UnknownMyco-Ed: Mycological curriculum for education and discovery.
Fungi are important and hyperdiverse organisms, yet chronically understudied. Most fungal clades have no reference genomes, impeding our understanding of their ecosystem functions and use as solutions in health and biotechnology. Also, opportunities for training in fungal biology and genomics are la...
S-EPMC12273965 | biostudies-literature
UnknownTreatment of nonalcoholic fatty liver disease in children: TONIC trial design.

Background

Nonalcoholic fatty liver disease (NAFLD) in children can lead to steatohepatitis, cirrhosis, and end-stage liver disease. The cause of NAFLD is unknown, but it is commonly associated with obesity, insulin resistance, and dyslipidemia.

Objectives

TONIC is conducted to test w...
S-EPMC2936451 | biostudies-literature
UnknownAssessing vascular effects of adding bevacizumab to neoadjuvant chemotherapy in osteosarcoma using DCE-MRI.

Background

The purpose of this study was to assess the impact of bevacizumab alone and in combination with cytotoxic therapy on tumour vasculature in osteosarcoma (OS) using DCE-MRI.

Methods

Six DCE-MRI and three (18)F-FDG PET examinations were scheduled in 42 subjects with newly diag...
S-EPMC4815789 | biostudies-literature
UnknownNASH resolution is associated with improvements in HDL and triglyceride levels but not improvement in LDL or non-HDL-C levels.

Background

Nonalcoholic steatohepatitis (NASH) is associated with dyslipidemia and cardiovascular disease (CVD).

Aim

To determine the relationship between resolution of NASH and dyslipidemia.

Methods

Individuals in the Pioglitazone vs. Vitamin E vs. Placebo for the Treatment of...
S-EPMC4424085 | biostudies-literature
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