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UnknownFBP21's C-Terminal Domain Remains Dynamic When Wrapped around the c-Sec63 Unit of Brr2 Helicase.
Not available
S-EPMC6372199 | biostudies-literature
UnknownNFAT5 Isoform C Controls Biomechanical Stress Responses of Vascular Smooth Muscle Cells.
Not available
S-EPMC6115610 | biostudies-literature
UnknownThe C-terminal coiled-coil domain of Corynebacterium diphtheriae DIP0733 is crucial for interaction with epithelial cells and pathogenicity in invertebrate animal model systems.
Not available
S-EPMC6123952 | biostudies-literature
TranscriptomicsCaM Kinase II mediates maladaptive post-infarct remodeling but not acute myocardial ischemia/reperfusion injury
Calcium/calmodulin-dependent protein kinase II (CaMKII) was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. However, the specific functions of the CaMKII isoforms and splice variants in ischemia/reperfusion (I/R) injury have not been investigated yet. Thus, we studied...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-58486 | biostudies-arrayexpress
UnknownThe conformational stability of nonfibrillar amyloid-β peptide oligomers critically depends on the C-terminal peptide length.
Not available
S-EPMC3963130 | biostudies-literature
UnknownHIV-1 fusion is blocked through binding of GB Virus C E2-derived peptides to the HIV-1 gp41 disulfide loop [corrected].
Not available
S-EPMC3551756 | biostudies-literature
TranscriptomicsCarcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications
We here show that loss of imprinting (LOI) of IGF2 is a frequent and early event in the development of colon cancer and occurs throughout the large intestine. LOI leads to AKT1-dependent activation and suppression of a defined set of genes, many of which are cell cycle related. Our results further s...
ORGANISM(S): Homo sapiens 
2016-07-04 | E-GEOD-66726 | biostudies-arrayexpress
TranscriptomicsFIR inhibition in HCC cells (Hep3B)
siRNA-mediated inhibition compared to untreated cells and cells transfected with nonsense siRNA Together with far upstream element binding protein (FBP), the FBP-interacting repressor (FIR) represents a molecular tool for the transcriptional fine tune regulation of target genes. Previous evidence in...
ORGANISM(S): Homo sapiens 
2014-09-03 | E-GEOD-55692 | biostudies-arrayexpress
TranscriptomicsEngineering endochondral ossification using Sonic Hedgehog for bone regeneration
Endochondral ossification (EO) is the natural route for the regeneration of large and mechanically challenged bone defects. Regeneration occurs via a fibrocartilagenous phase which turns into bone upon vascularization and the formation of a transient collagen type X extra cellular matrix. These two ...
ORGANISM(S): Homo sapiens 
2012-09-01 | E-GEOD-22293 | biostudies-arrayexpress
TranscriptomicsSynergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8A.
Tumor-associated macrophages (TAMs) represent alternatively activated (M2) macrophages that support tumor growth. Previously, we have described a special LYVE-1(+) M2 TAM subset in vitro and in vivo; gene profiling of this TAM subset identified MS4A8A as a novel TAM molecule expressed in vivo by TAM...
ORGANISM(S): Mus musculus 
2012-05-22 | E-GEOD-38171 | biostudies-arrayexpress
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