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TranscriptomicsCarcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications
We here show that loss of imprinting (LOI) of IGF2 is a frequent and early event in the development of colon cancer and occurs throughout the large intestine. LOI leads to AKT1-dependent activation and suppression of a defined set of genes, many of which are cell cycle related. Our results further s...
ORGANISM(S): Homo sapiens 
2016-07-04 | E-GEOD-66726 | biostudies-arrayexpress
TranscriptomicsStretch-dependent genes in vascular smooth muscle cells
Vascular smooth muscle cells (VSMCs) respond to biomechanical stretch with specific changes in gene expression which govern the phenotype of these cells. The mechanotransducer zyxin is a potential candidate for regulating the expression of such genes. Using microarrays, we compared stretch-induced ...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-60447 | biostudies-arrayexpress
TranscriptomicsSynergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8A.
Tumor-associated macrophages (TAMs) represent alternatively activated (M2) macrophages that support tumor growth. Previously, we have described a special LYVE-1(+) M2 TAM subset in vitro and in vivo; gene profiling of this TAM subset identified MS4A8A as a novel TAM molecule expressed in vivo by TAM...
ORGANISM(S): Mus musculus 
2012-05-22 | E-GEOD-38171 | biostudies-arrayexpress
TranscriptomicsIdentification of drought stress related genes in NatA depleted mutants
N-terminal protein acetylation is one of the most common protein modifications in eucaryotes and is catalyzed co-translationally by N-terminal aceytltransferases (Nats). Regarding the number of predictaed substrates, NatA is the main Nat complex in human and yeast and is composed of the catalytic su...
ORGANISM(S): Arabidopsis thaliana 
2015-07-23 | E-GEOD-65414 | biostudies-arrayexpress
TranscriptomicsTranscriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer fatalities in Western societies, characterized by high metastatic potential and resistance to chemotherapy. Critical molecular mechanisms of these phenotypical features still remain unknown, thus hampering the development ...
ORGANISM(S): Homo sapiens 
2015-06-16 | E-GEOD-59761 | biostudies-arrayexpress
TranscriptomicsCaM Kinase II mediates maladaptive post-infarct remodeling but not acute myocardial ischemia/reperfusion injury
Calcium/calmodulin-dependent protein kinase II (CaMKII) was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. However, the specific functions of the CaMKII isoforms and splice variants in ischemia/reperfusion (I/R) injury have not been investigated yet. Thus, we studied...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-58486 | biostudies-arrayexpress
TranscriptomicsOpen lung approach with low tidal volume mechanical ventilation attenuates lung injury in rats with massive brain damage
Introduction: The ideal ventilation strategy for patients with massive brain damage requires better elucidation. We hypothesized that in the presence of massive brain injury, a ventilation strategy using low (6 mL/kg) tidal volume (VT) ventilation with open lung positive end-expiratory pressure set ...
ORGANISM(S): Rattus norvegicus 
2014-04-24 | E-GEOD-52142 | biostudies-arrayexpress
TranscriptomicsIn vivo and in vitro investigations of heterozygous nebulin knock-out mice reveal similarities with mild human form of nemaline myopathy [mRNA]
In the present study, we used a multimodal approach including protein and gene expression analysis and combined in vivo and in vitro measurements of force production. Overall, we aimed at investigating the functional impact of the expression of a single nebulin allele. Comparison of the mRNA express...
ORGANISM(S): Mus musculus 
2012-09-01 | E-GEOD-36743 | biostudies-arrayexpress
TranscriptomicsExpression Profiling of Oral Squamous Cell Carcinoma and Mucosa of healthy non-tumor patients
In an attempt to further elucidate the pathomechanisms in oral squamous cell carcinoma (OSCC), gene expression profiling to a set of 35 primary OSCCs compared to 6 oral mucosa from healthy non-tumor patients was performed. Keywords: expression profiling Gene expression profiling using a whole-transc...
ORGANISM(S): Homo sapiens 
2008-01-12 | E-GEOD-10121 | biostudies-arrayexpress
TranscriptomicsFetal mesenchymal stromal cells differentiating towards chondrocytes acquire a gene expression profile resembling human growth plate cartilage.
We used human fetal bone marrow-derived mesenchymal stromal cells (hfMSCs) differentiating towards chondrocytes as an alternative model for the human growth plate (GP). Our aims were to study gene expression patterns associated with chondrogenic differentiation to assess whether chondrocytes derived...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-40942 | biostudies-arrayexpress
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