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TranscriptomicsPPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism.
Peroxisome proliferator-activated receptor alpha (PPARα) is a key regulator of hepatic fat oxidation that serves as an energy source during starvation. Vanin-1 has been described as a putative PPARα target gene in liver, but its function in hepatic lipid metabolism is unknown. We investigated the ...
ORGANISM(S): Mus musculus 
2014-04-24 | E-GEOD-51712 | biostudies-arrayexpress
TranscriptomicsPPARγ activation promotes infiltration of alternatively activated macrophages into adipose tissue.
Background: Obesity is associated with infiltration of macrophages into adipose tissue. Adipose macrophages may contribute to an elevated inflammatory status by secreting a variety of pro-inflammatory mediators, including TNFalpha and IL-6. Recent data suggest that during diet-induced obesity the ph...
ORGANISM(S): Mus musculus 
2008-04-29 | E-GEOD-11295 | biostudies-arrayexpress
TranscriptomicsKupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity.
Kupffer cells have been implicated in the pathogenesis of various liver diseases. However, their involvement in metabolic disorders of the liver, including fatty liver disease, remains unclear. The present study sought to determine the impact of Kupffer cells on hepatic triglyceride storage and to e...
ORGANISM(S): Mus musculus 
2011-10-17 | E-GEOD-33044 | biostudies-arrayexpress
TranscriptomicsCD1d-restricted NKT cell function prevents insulin resistance in lean mice, and is regulated by adipocytes and is regulated by adipocytes
Lipid overload and adipocyte dysfunction are key to the development of insulin resistance and can be induced by a high-fat diet. CD1d-restricted invariant natural killer T (iNKT) cells have been proposed as mediators between lipid overload and insulin resistance, but recent studies found decreased i...
ORGANISM(S): Mus musculus 
2012-08-06 | E-GEOD-39534 | biostudies-arrayexpress
TranscriptomicsIL-37 protects against obesity-induced inflammation and insulin resistance
Cytokines of the IL-1 family are important modulators of obesity-induced inflammation and the development of systemic insulin resistance. Here, we report that IL-37, a newly-described antiinflammatory member of the IL-1 family, affects obesity-induced inflammation and insulin resistance. IL-37 trans...
ORGANISM(S): Mus musculus 
2015-05-18 | E-GEOD-58952 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat livers with inactivated PPARI
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8302 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse 3-5 months old males wild-type (129S1/SvImJ) and PPARalpha-null (129S4/SvJae) to investigate PPARalpha-dependent regulation of hepatic lipid metabolism - 4
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8295 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver from wild-type (129S1/SvImJ) and PPARalpha-null (129S4/SvJae) animals treated with WY14643 vs. controls - 3
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8292 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild-type and PPARI?-null liver treated with the synthetic PPARI? ligand WY14643
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8291 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver wild type and PPARI?-nulls -1
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8290 | biostudies-arrayexpress
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