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UnknownQuantitative DNA methylation analysis identifies a single CpG dinucleotide important for ZAP-70 expression and predictive of prognosis in chronic lymphocytic leukemia.
Not available
S-EPMC3397783 | biostudies-literature
TranscriptomicsMiRNA expression in chronic lymphocytic leukemia
MiRNA expression is known to be deregulated in chronic lymphocytic leukemia (CLL). To get insight into miRNA expression pattern in CLL, we compaired miRNA expression profiling of peripheral blood-derived CLL cells and the healthy donor, peripheral blood-derived B-lymphocytes. A set of differentially...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-31599 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of genetically and clinically distinct subgroups of human B-cell chronic lymphocytic leukemia patients
We used high density oligonucleotide arrays to identify molecular correlates of genetically and clinically distinct subgroups of B-cell chronic lymphocytic leukemia (B-CLL). Gene expression profiling was used to profile the five most frequent genomic aberrations, namely deletions affecting chromosom...
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2466 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Expression Profiling of cultured B-CLL cells
Increased survival of primary B-CLL cells cultured in high cell density: Evidence for activation of pathways also induced by stromal cells. Expression profiles of B-CLL cells before and after three different survival-inducing culture conditions: (1) stromal cell coculture [HCo], (2) stromal cell con...
ORGANISM(S): Homo sapiens 
2010-09-21 | E-GEOD-18192 | biostudies-arrayexpress
GenomicsAnalysis of DNA methylation in normal B cells and chronic lymphocytic leukemia
Charting differences between tumors and normal tissue is a mainstay of cancer research. However, clonal tumor expansion from complex normal tissue architectures potentially obscures cancer-specific events, including divergent epigenetic patterns. Using whole-genome bisulfite sequencing of normal B c...
EGAS00001000534 | EGA
Genomicsena-DATASET-DKFZ-Epigenomics-19-11-2015-09:37:32:058-207 - samples
RNA-seq of peripheral blood samples from CLL patients.
EGAD00001001675 | EGA
Genomicsena-DATASET-DKFZ-Epigenomics-19-11-2015-09:41:10:900-208 - samples
Tagmentation-based whole-genome bisulfite sequencing of isolated cell types from healthy controls.
EGAD00001001676 | EGA
Genomics450K_DKFZ_CLL_NB
CLL and normal B cell samples using 450K
EGAD00010000871 | EGA
GenomicsData Access Committee of DKFZ-Epigenomics
Data Access Committee EGAC00001000279
EGAC00001000279 | EGA
TranscriptomicsGene expression profiling in isogenic p53wt/p53ko Burkitt lymphoma cell line Seraphine after shRNA-mediated knock-down of p53 pathway members
We performed an shRNA-based RNAi interference screen targeting around 5,000 genes in eight Burkitt lymphoma cell lines. MDM4 and CDKN3 were essential genes in four p53 wild-type Burkitt lymphoma cell lines, but not in four p53 mutant cell lines. To investigate the effect of the gene knock-down on ce...
ORGANISM(S): Homo sapiens 
2019-08-01 | E-MTAB-7134 | biostudies-arrayexpress
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