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MetabolomicsImmune Stimulation via Wounding Alters Chemical Profiles of Adult Tribolium castaneum
Group-living individuals experience immense risk of disease transmission and parasite infection. In social and in some non-social insects, disease control with immunomodulation arises not only via individual immune defenses, but also via infochemicals such as contact cues and (defensive) volatiles t...
2023-04-24 | MTBLS2277 | MetaboLights
MetabolomicsUntargeted metabolomics profiling to determine FITM2-dependent metabolic rewiring under IFNγ stimulation
This study aimed to define metabolic alterations associated with FITM2 loss in tumor cells exposed to inflammatory cytokine signaling. KPC control and FITM2 knockout cells were treated with IFNγ and subjected to untargeted metabolomics profiling using LC–MS/MS. Data from positive and negative ioniza...
2026-04-11 | MTBLS14254 | MetaboLights
TranscriptomicsExpression data from advanced Parkinson's disease (PD) patients leukocytes - prior to and following deep brain stimulation (DBS) treatment in on and off stimulation conditions, and matched healthy control (HC) subjects
Sub-thalamic deep brain stimulation (DBS) reversibly modulates ParkinsonM-bM-^@M-^Ys disease (PD) motor symptoms, providing an unusual opportunity to compare leukocyte transcripts in the same subjects before and after neurosurgery and after disconnecting the stimulus (ON-and OFF-stimulus). Here, we ...
ORGANISM(S): Homo sapiens 
2012-01-09 | E-GEOD-23676 | biostudies-arrayexpress
TranscriptomicsMouse Soleus Muscle Chronic Electrical Stimulation Study
Stimulation of the mouse hindlimb via the sciatic nerve was used to induce contractions for 4 hours to investigate acute muscle gene activation in a model of muscle phenotype conversion. Initial force production (1.6 + 0.1 g/g body weight) declined 45% within 10 min and was maintained for the remain...
ORGANISM(S): Mus musculus 
2010-06-01 | E-GEOD-14391 | biostudies-arrayexpress
MetabolomicsOptimised LC-MS Metabolomic Profiling Reveals Emergent Changes to Monocyte Metabolism in Response to Lipopolysaccharide
Immunometabolism examines the links between immune cell function and metabolism. Dysregulation of immune cell metabolism is now an established feature of innate immune cell activation. Advances in liquid chromatography mass spectrometry (LC-MS) technologies have allowed discovery of unique insights ...
2025-11-17 | MTBLS6730 | MetaboLights
TranscriptomicsHuman Splice Junction Arrays of Parkinson's Patients Leukocytes mRNA Pre- and Post-Deep Brain Stimulation
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide and the first involving motor symptoms. Deep brain stimulation (DBS) neurosurgery treatment through electrodes implanted to the subthalamic nucleus (STN) improves dramatically the debilitating motor symptoms of th...
ORGANISM(S): Homo sapiens 
2015-05-22 | E-GEOD-37591 | biostudies-arrayexpress
UnknownShort trains of transcutaneous auricular vagus nerve stimulation (taVNS) have parameter-specific effects on heart rate.
Not available
S-EPMC6536129 | biostudies-literature
TranscriptomicsDeep sequencing of the small RNA transcriptome of blood leukocytes from Parkinson's disease patients prior to and following deep brain stimulation (DBS) and as compared with healthy control volunteers
We report the application of small RNA sequencing technology for high-throughput profiling of microRNA molecules (miRNAs) in blood leukocytes of Parkinson's Disease (PD) patients. Expression changes which may contribute to PD pathogenesis and reaction to treatment were identified in RNA preparations...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-GEOD-40915 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of rat myocardial slices cultured with biomimetic electromechanical stimulation
Adult cardiac tissue undergoes a rapid process of dedifferentiation when cultured in vitro. The aim of this experiment was to compare the transcriptome of freshly prepared rat myocardial slices with slices cultured in unloaded conditions (no electromechanical stimulation) for 24 hours, electromecha...
ORGANISM(S): Rattus norvegicus 
2019-04-17 | E-MTAB-7842 | biostudies-arrayexpress
ProteomicsCulture and stimulation conditions influence protein expression of primary fibroblasts
Tissue fibrosis is a common pathway to organ injury and failure. It is characterized by an excessive deposition of extracellular matrix (ECM) in organs. Deciphering the fibrogenic processes is of utmost importance, as there are few effective therapies in fibrotic diseases 1. Systemic sclerosis (SSc)...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD025374 | Pride
Mass spectrometry Fibrosis Primary fibroblasts Tgf-β1 Systemic sclerosis 
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