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TranscriptomicsEffect of oligomycin on transcript levels in Arabidopsis seedling cultures
To understand how an inhibition of the mitochondrial ATP synthase affects transcriptional programming and to identify potential candidates of the signaling machinery involved in ATP synthase deficiency responses, we used oligomycin on seedling liquid cultures. Seedlings were harvested at time points...
ORGANISM(S): Arabidopsis thaliana 
2012-06-27 | E-GEOD-38965 | biostudies-arrayexpress
GenomicsGenomic sequencing of T. brucei cell lines resistant to AN7973
Wild type T. brucei bloodstream form were incubated with increasing concentrations of AN7973, a benzoxaborole compound developed by Anacor Pharmaceuticals Inc. against Animal African Trypanosomiasis. Cells had a tendency to lose resistance, only roughly 2x EC50 resistance was obtained. This experime...
ORGANISM(S): Trypanosoma brucei brucei 
2018-06-04 | E-MTAB-6307 | biostudies-arrayexpress
TranscriptomicsmRNA profiling of NMuMG mouse mammary epithelial cells transformed in vitro by long-term incubation in the presence of aluminium chloride vs controls incubated in parallel in the presence of the same dilution of solvent (H2O) alone. Referred to as \"NMuMG series III\" in the citing manuscript (Mandriota et al., submitted).
Salts of aluminium, a chemical element devoid of biological function, are added to many industrial products of frequent use because of aluminium's chemical versatility. As a result of lifetime exposure, aluminium accumulates in several organs including the mammary gland. At concentrations in the ran...
ORGANISM(S): Mus musculus 
2020-11-30 | E-MTAB-9735 | biostudies-arrayexpress
TranscriptomicsmRNA profiling of HC11 mouse mammary epithelial cells incubated for 4 weeks in the presence of aluminium chloride vs controls incubated in parallel in the presence of the same dilution of solvent (H2O) alone
Salts of aluminium, a chemical element devoid of biological function, are added to many industrial products of frequent use because of aluminium's chemical versatility. As a result of lifetime exposure, aluminium accumulates in several organs including the mammary gland. At concentrations in the ran...
ORGANISM(S): Mus musculus 
2020-11-30 | E-MTAB-9763 | biostudies-arrayexpress
TranscriptomicsmRNA profiling of HC11 mouse mammary epithelial cells transformed in vitro by long-term incubation in the presence of aluminium chloride vs controls incubated in parallel in the presence of the same dilution of solvent (H2O) alone.
Salts of aluminium, a chemical element devoid of biological function, are added to many industrial products of frequent use because of aluminium's chemical versatility. As a result of lifetime exposure, aluminium accumulates in several organs including the mammary gland. At concentrations in the ran...
ORGANISM(S): Mus musculus 
2020-11-30 | E-MTAB-9723 | biostudies-arrayexpress
TranscriptomicsmRNA profiling of NMuMG mouse mammary epithelial cells incubated for 4 weeks in the presence of aluminium chloride vs controls incubated in parallel in the presence of the same dilution of solvent (H2O) alone
Salts of aluminium, a chemical element devoid of biological function, are added to many industrial products of frequent use because of aluminium's chemical versatility. As a result of lifetime exposure, aluminium accumulates in several organs including the mammary gland. At concentrations in the ran...
ORGANISM(S): Mus musculus 
2020-11-30 | E-MTAB-9764 | biostudies-arrayexpress
TranscriptomicsmRNA profiling of NMuMG mouse mammary epithelial cells transformed in vitro by long-term incubation in the presence of aluminium chloride vs controls incubated in parallel in the presence of the same dilution of solvent (H2O) alone. Referred to as \\"NMuMG series I\\" in the citing manuscript (Mandriota et al., submitted).
Salts of aluminium, a chemical element devoid of biological function, are added to many industrial products of frequent use because of aluminium's chemical versatility. As a result of lifetime exposure, aluminium accumulates in several organs including the mammary gland. At concentrations in the ran...
ORGANISM(S): Mus musculus 
2020-11-30 | E-MTAB-9733 | biostudies-arrayexpress
MetabolomicsMulti-omics analysis reveals microbiota-metabolite crosstalk in MASLD pathogenesis in a non-obese murine model

The rising global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), including its severe form metabolic dysfunction-associated steatohepatitis (MASH), underscores the urgency to elucidate its pathophysiology. To investigate key metabolic interactions central to MASLD...

2026-03-13 | MTBLS14048 | MetaboLights
GenomicsA SNF2 protein targets variable copy number repeats and thereby influences allele-specific expression
ATRX is an X-linked gene of the SWI/SNF family whose role in vivo is currently unknown. Mutations in ATRX cause syndromal mental retardation. ATRX binds to tandem repeat (TR) sequences both in heterochromatin (e.g. telomeres) and euchromatin. Genes associated with these TRs can be dysregulated when ...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-22162 | biostudies-arrayexpress
GenomicsPCGP Ph-like ALL
Background: BCR-ABL1-like, or Ph-like acute lymphoblastic leukemia is characterized by a gene expression profile similar to BCR-ABL1 positive ALL, genetic alterations of lymphoid transcription factor genes, and poor outcome. Sequencing of small numbers of Ph-like ALL cases has identified genetic alt...
EGAS00001000654 | EGA
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