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TranscriptomicsTranscription profiling of mouse RAG1 knockout CD4+ T cells to investigate the effect of absence of interaction with MHC class II on memory CD4 T cells
Effect of absence of interaction with MHC class II on memory CD4 T cells
ORGANISM(S): Mus musculus 
2007-03-01 | E-MEXP-890 | biostudies-arrayexpress
TranscriptomicsATAC-seq examining chromatin accessibility of mouse splenic IL-10+ and IL-10-CD19+CD21hiCD24hi B cells
Chromatin profiling of mouse splenic ex-vivo IL-10+, IL-10-CD19+CD21hiCD23hiCD24hi B cells and IL-10- follicular B cells, after antigen induced arthritis. IL-10eGFP reporter (Vert-X) mice were used to sort IL-10+ and IL-10- subsets. ATAC-seq was used in conjunction with microarray data to understand...
ORGANISM(S): Mus musculus 
2019-10-09 | E-MTAB-8393 | biostudies-arrayexpress
TranscriptomicsEnvironmental factors transmitted by aryl hydrocarbon receptor influence severity of psoriatic skin inflammation [RNA-Seq]
Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other autoimmune diseases, but the mechanism is unknown. Here we show that the aryl hydrocarbon receptor (AhR), a transcription factor that senses environmental stimuli, modulates pathology in psoriasis. AhR-activati...
ORGANISM(S): Homo sapiens 
2014-06-11 | E-GEOD-47944 | biostudies-arrayexpress
TranscriptomicsEnvironmental factors transmitted by aryl hydrocarbon receptor influence severity of psoriatic skin inflammation [Affymetrix]
Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other autoimmune diseases, but the mechanism is unknown. Here we show that the aryl hydrocarbon receptor (AhR), a transcription factor that senses environmental stimuli, modulates pathology in psoriasis. AhR-activati...
ORGANISM(S): Mus musculus 
2014-06-11 | E-GEOD-47607 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human Th17 cell differentiation
The study aims at identifying transcriptional changes induced by in vitro polarization of human cord blood CD4+ cells towards Th17 subtype with combination of IL6, IL1b and TGFb by using timeseries data. In this study, we identified gene expression changes characterizing early stages of human Th17 c...
ORGANISM(S): Homo sapiens 
2012-05-03 | E-GEOD-35103 | biostudies-arrayexpress
TranscriptomicsComparative analysis of human and mouse transcriptomes of Th17 cell priming.
Uncontrolled Th17 cell activity is associated with cancer and autoimmune and inflammatory diseases. To validate the potential relevance of mouse models of targeting the Th17 pathway in human diseases we used RNA sequencing to compare the expression of coding and non-coding transcripts during the pri...
ORGANISM(S): Homo sapiens 
2016-04-07 | E-GEOD-52260 | biostudies-arrayexpress
TranscriptomicsTc17 cells are a pro-inflammatory, plastic lineage of pathogenic CD8+ T-cells that induce GVHD without anti-leukemic effects
IL-17-producing cells are important mediators of graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (SCT). Here we demonstrate that a distinct CD8+ Tc17 population develops rapidly after SCT but fails to maintain lineage fidelity such that they are unrecognizable in the abse...
ORGANISM(S): Mus musculus 
2015-09-13 | E-GEOD-70931 | biostudies-arrayexpress
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