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TranscriptomicsExpression microarray analysis of human pancreatic islets reveals CD59 function
Pancreatic islets are central in type 2-diabetes development, which coincides with increased activity of innate immunity. Intriguingly, human pancreatic islets express many complement genes. The most highly expressed gene was the complement inhibitor CD59 that is GPI anchored to the cell membrane, w...
ORGANISM(S): Homo sapiens 
2014-03-02 | E-GEOD-54279 | biostudies-arrayexpress
TranscriptomicsC4b-binding protein protects beta-cells from islet amyloid polypeptide induced cytotoxicity.
Complement inhibitor C4b-binding protein (C4BP) is synthesized in liver and pancreas and composed of 7 identical alpha chains and one unique beta chain. We showed previously that C4BP binds islet amyloid polypeptide (IAPP) and affects fibril formation in vitro. Now we found that polymeric C4BP inhib...
ORGANISM(S): Rattus norvegicus 
2016-08-25 | E-GEOD-79224 | biostudies-arrayexpress
TranscriptomicsGene expression profile in patients inoculated with E. coli 83972
Urinary tract infections (UTIs) constitute a highly relevant model of microbial adaptation, in which the contrasting effects of pathogens and commensals on host tissues are clearly displayed. While virulent Escherichia coli cause severe, potentially life-threatening disease by breaking the inertia o...
ORGANISM(S): Homo sapiens 
2013-02-23 | E-GEOD-43838 | biostudies-arrayexpress
TranscriptomicsWhy does HAMLET preferentially kill tumor cells? p38-dependent death in tumor but up-regulation of innate immunity in healthy, differentiated cells
HAMLET triggers a p38- and ER stress-dependent death response in carcinoma cells. Transcriptome and proteome analysis detected an increase in p38 expression and phosphorylation exclusively in carcinoma cells and p38 inhibitors delayed the death response to HAMLET in carcinoma and lymphoma cells. ER...
ORGANISM(S): Homo sapiens 
2010-08-24 | E-GEOD-23772 | biostudies-arrayexpress
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