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TranscriptomicsGenome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays
This series represents 52 tissues hybridized across 5 different chip patterns. Probes were placed at every exon-exon junction in each transcript. Keywords = junction alternate splicing oligonucleotide Keywords: parallel sample. This dataset is part of the TransQST collection.
ORGANISM(S): Homo sapiens 
2003-12-19 | E-GEOD-740 | biostudies-arrayexpress
TranscriptomicsExpression profiling of liver tissue from C57BL6 x DBA strain
Expression profiling of liver tissue from 111 F2 female mice resulting from a cross between C57BL/6J and DBA/2J inbred mouse strains. Mice were feed a chow diet for 12 months followed by 4 months on an atherogenic high-fat, high-cholesterol diet. Parental and F2 mice were killed at 16 months of age....
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-2008 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of beta-catenin regulated target genes in SW480 colon cancer cells
Deregulation of the canonical Wnt/beta-catenin pathway is one of the earliest events in the pathogenesis of colon cancer. Mutations in APC or CTNNB1 are frequent in colon cancer and cause aberrant stabilization of beta-catenin, which activates Wnt target genes by binding to chromatin via TCF/LEF tra...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-53656 | biostudies-arrayexpress
TranscriptomicsHuman esophageal adenocarcinomas
The incidence of esophageal and junctional adenocarcinoma has increased 6 fold in the last 30 years and 5 year survival remains less than 14%. Most patients present with advanced disease and current staging is limited in its ability to predict survival. We aimed to generate and validate a molecular ...
ORGANISM(S): Homo sapiens 
2010-06-01 | E-GEOD-19417 | biostudies-arrayexpress
TranscriptomicsProfiling of Human Adipose Tissue and Effect of Sibutramine on Gene Expression
We analyzed the expression of 23,653 transcripts in the adipose tissue of 19 individuals treated with Sibutramine Keywords: sibutramine effect 157 adipose tissue samples from 19 individuals treated with sibutramin as well as placebo were profiled for gene expression.
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10545 | biostudies-arrayexpress
TranscriptomicsProfiling of adipose tissue from the F2 M16xICR mouse cross.
We profiled gene expression in adipose tissue from F2 progeny from a cross between the outbred M16 (selectively bred for rapid weight gain) and ICR (control) mouse strains. We developed a framework for reconstructing tissue-to-tissue coexpression networks between genes in hypothalamus, adipose or ad...
ORGANISM(S): Mus musculus 
2009-10-25 | E-GEOD-13746 | biostudies-arrayexpress
TranscriptomicsProfiling of hypothalamus tissue from the F2 M16xICR mouse cross.
We profiled gene expression in hypothalamus tissue from F2 progeny from a cross between the outbred M16 (selectively bred for rapid weight gain) and ICR (control) mouse strains. We developed a framework for reconstructing tissue-to-tissue coexpression networks between genes in hypothalamus, liver or...
ORGANISM(S): Mus musculus 
2010-06-22 | E-GEOD-13745 | biostudies-arrayexpress
TranscriptomicsProfiling of liver tissue from the F2 M16xICR mouse cross.
We profiled gene expression in liver tissue from F2 progeny from a cross between the outbred M16 (selectively bred for rapid weight gain) and ICR (control) mouse strains. We developed a framework for reconstructing tissue-to-tissue coexpression networks between genes in hypothalamus, liver or liver ...
ORGANISM(S): Mus musculus 
2009-10-25 | E-GEOD-13752 | biostudies-arrayexpress
TranscriptomicsMulti-tissue gene expression profiles of human brain (CR)
The genetics of complex disease produce alterations in molecular interactions of cellular pathways which collective effect may become clear through the organized structure of molecular networks. To characterize molecular systems associated with late-onset Alzheimer´s disease (LOAD), we constructed g...
ORGANISM(S): Homo sapiens 
2013-04-25 | E-GEOD-44768 | biostudies-arrayexpress
TranscriptomicsMulti-tissue gene expression profiles of human brain (PFC)
The genetics of complex disease produce alterations in molecular interactions of cellular pathways which collective effect may become clear through the organized structure of molecular networks. To characterize molecular systems associated with late-onset Alzheimer´s disease (LOAD), we constructed g...
ORGANISM(S): Homo sapiens 
2013-04-25 | E-GEOD-44770 | biostudies-arrayexpress
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