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TranscriptomicsThe MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs
Piwi-interacting RNAs (piRNAs) guide Piwi Argonautes to suppress transposon activity in animal gonads. Known piRNA populations are extremely complex, with millions of individual sequences present in a single organism. Despite this complexity, specific Piwi proteins incorporate piRNAs with distinct n...
ORGANISM(S): Bombyx mori 
2014-07-01 | E-GEOD-55451 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cerebellum from transgenic mice with nuclear and extranuclear polyQ to investigate the role of polyQ in Huntingtons disease
To dissect the impact of nuclear and extranuclear mutant htt on the initiation and progression of disease, we generated a series of transgenic mouse lines in which nuclear localization (NLS) or nuclear export sequences (NES) have been placed N-terminal to the htt exon 1 protein carrying 144 glutamin...
ORGANISM(S): Mus musculus 
2007-07-03 | E-GEOD-3248 | biostudies-arrayexpress
UnknownDysregulation of hair-strand-based elemental biodynamics in amyotrophic lateral sclerosis.
Not available
S-EPMC12444149 | biostudies-literature
TranscriptomicsA function for the hnRNP A1/A2 proteins in transcription elongation
The hnRNP A1 and A2 proteins regulate processes such as alternative pre-mRNA splicing and mRNA stability. Here, we report that a reduction in the levels of hnRNP A1 and A2 by RNA interference or their cytoplasmic retention by osmotic stress drastically increases the transcription of a reporter gene....
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-67617 | biostudies-arrayexpress
GenomicsGenome wide profiling of MBD2 binding
We show that in vivo MBD2 is mainly recruited to CpG island promoters that are highly methylated. We also report that MBD2 binds to a subset of CpG island promoters that are characterized by the presence of active histone marks and RNA polymerase II (Pol2). At such sites, MBD2 binds downstream of th...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-54693 | biostudies-arrayexpress
GenomicsOrigins and functional consequence of somatic mitochondrial DNA mutations
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mitochondrial DNA (mtDNA) are unclear. Here, we analysed soma...
EGAS00001000968 | EGA
TranscriptomicsMaternal inhalation of surface-coated nano-sized titanium dioxide (UV-Titan): Effects in prenatally exposed offspring on hepatic DNA damage and gene expression
In the present study we investigate the effect of maternal pulmonary exposure to titanium dioxide (UV-Titan designed for use in the paint and lacquer industry) on prenatally exposed offspring. Time-mated mice (C57BL/6BomTac) were exposed by inhalation for 1 h/day to 42 mg UV-titan/m3 aerosolized pow...
ORGANISM(S): Mus musculus 
2012-03-19 | E-GEOD-29067 | biostudies-arrayexpress
UnknownA wearable aptamer nanobiosensor for non-invasive female hormone monitoring.
Not available
S-EPMC10954395 | biostudies-literature
TranscriptomicsTranscription profiling of Salmonella enterica serovar Typhimurium SL1344 and a SL1344 ramA gene knockout
The transcriptomes of Salmonella enterica serovar Typhimurium SL1344 and SL1344 lacking a functional ramA were compared
ORGANISM(S): Salmonella enterica 
2009-12-31 | E-MEXP-2193 | biostudies-arrayexpress
TranscriptomicsHigh-throughput RNA sequencing of six ant transcriptomes
RNA sequencing data was used to identify novel viral positive-strand RNA virus genomes within ant transcriptomes.
ORGANISM(S): Lasius niger 
2017-10-24 | E-MTAB-5781 | biostudies-arrayexpress
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