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ProteomicsATM Inhibition Exploits Checkpoint Defects and ATM-Dependent Double Strand Break Repair in TP53-Mutant Glioblastoma
Determining the balance between DNA double strand break repair (DSBR) pathways is essential for understanding treatment response in cancer. We report a novel method for simultaneously measuring non-homologous end joining (NHEJ), homologous recombination (HR), and microhomology-mediated end joining (...
ORGANISM(S): Homo sapiens (Human) 
2024-03-08 | PXD047837 | Pride
Dna double strand break repair Tp53-mutant glioblastoma Atm inhibition 
TranscriptomicsRNA-seq from ENCODE/Caltech
This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (mailto:georgi@caltech.edu for data coordination/informatics/experimental questions, mailto:diane@caltech.edu for informatics questions, mailto:bawilli_91125@yahoo.com for experimental...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-33480 | biostudies-arrayexpress
TranscriptomicsThe response of Extra-intestinal Pathogenic Escherichia coli to human serum
In this study the transcriptional response of an ExPEC E. coli strain (CFT073) to human serum was investigated. In response, CFT073 up-regulated expression of iron and manganese acquisition systems and induced expression of iron regulated genes. High osmolarity of serum induced the osmotic shock res...
ORGANISM(S): Escherichia coli 
2013-10-20 | E-MTAB-1985 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of lung-infiltrating neutrophils from WT and Atgl-cKO mice
Atglflox/flox (B6N.129S-Pnpla2tm1Eek/J), S100A8-cre+/- (B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J) mice were obtained from The Jackson Laboratory. Atglflox/flox mice were bred to S100A8-cre+/- mice to generate Atglflox/WTS100A8-cre+/- mice, which were backcrossed onto Atglflox/flox mice to generate Atglflox/...
ORGANISM(S): Mus musculus 
2020-06-28 | E-MTAB-9235 | biostudies-arrayexpress
UnknownForster resonance energy transfer as a probe of membrane protein folding.
Not available
S-EPMC3253952 | biostudies-literature
GenomicsProteo-Genomic Characterization and Mapping of Nucleosomes Decoded by Brd and HP1 Proteins (Chip-Seq data)
Background: Histone post-translational modifications (PTMs) constitute a branch of epigenetic mechanisms that can control the expression of eukaryotic genes in a heritable manner. Recent studies have identified several PTM-binding proteins containing diverse specialized domains whose recognition of ...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-39579 | biostudies-arrayexpress
TranscriptomicsEvaluation of quantitative miRNA gene expression platforms in the microRNA Quality Control (miRQC) study
MiRNAs are important negative regulators of protein coding gene expression, and have been studied intensively over the last few years. Several measurement platforms, designed to determine their relative RNA abundance levels in biological samples, have been developed. In this study, we systematically...
ORGANISM(S): Homo sapiens 
2013-08-31 | E-GEOD-49816 | biostudies-arrayexpress
TranscriptomicsMaternal Influence on Exonic CpG Island Methylation in the Developing Hippocampus
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-35856 | biostudies-arrayexpress
TranscriptomicsENCODE Caltech RNA-seq
This data was produced by the Wold lab at Caltech as part of the ENCODE Project. RNA-Seq is a method for mapping and quantifying the transcriptome of any organism that has a genomic DNA sequence assembly. RNA-Seq is performed by reverse-transcribing an RNA sample into cDNA, followed by high throughp...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-23316 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of breast cancer (HCC1954) and normal breast cells (HMEC)
While genetic mutation is a hallmark of cancer, many cancers also acquire epigenetic alterations during tumorigenesis including aberrant DNA hypermethylation of tumor suppressors as well as changes in chromatin modifications as caused by genetic mutations of the chromatin-modifying machinery. Howeve...
ORGANISM(S): Homo sapiens 
2011-09-16 | E-GEOD-29119 | biostudies-arrayexpress
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