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GenomicsWhole-genome landscape of histone H2AX and M-NM-3-H2AX
Phosphorylation of the histone variant H2AX forms M-NM-3-H2AX that marks DNA double-strand break (DSB). Here we generated the sequencing-based maps of H2AX and M-NM-3-H2AX positioning in resting and proliferating cells before and after ionizing irradiation. Genome-wide locations of possible endoge...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-25577 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of talon-citrus clementina fruit flesh development
Global analysis of gene expression during development and ripening of citrus fruit flesh. Samples taken from fruit development phases I,II and III (Bain JM, 1958, Aust J Bot, 6: 1-24 ) were compared
ORGANISM(S): Citrus clementina 
2006-09-21 | E-MEXP-435 | biostudies-arrayexpress
ProteomicsNovel chemotherapy selectively induces double-strand DNA breaks and death in naïve and Cisplatin-resistant cholangiocarcinoma tumours - total proteomics and phosphoproteomics
Background & Aims: Patients with cholangiocarcinoma (CCA) have poor prognosis. Current first-line chemotherapy, including Cisplatin and Gemcitabine, provides limited survival benefits due to the development of chemoresistance. Cisplatin induces single-strand DNA breaks, activating DNA repair mechani...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD061935 | Pride
Cancer cells  cancer-associated fibroblasts  chemoresistance  novel therapy  dna crosslinks  chromatin remodeling Phosphoproteomics Label free 
TranscriptomicsPriming defense genes and metabolites in hybrid poplar by the green leaf volatile cis-3-hexenyl acetate
• Herbivore-induced plant volatiles (HIPVs), in addition to attracting natural enemies of herbivores, can serve a signaling function within plants by acting as wound signals that induce or prime defenses. However, particularly in woody plants, which compounds within HIPV blends are capable of act...
ORGANISM(S): Populus x canadensis 
2010-05-25 | E-GEOD-11955 | biostudies-arrayexpress
UnknownAsymmetric histone inheritance via strand-specific incorporation and biased replication fork movement.
Not available
S-EPMC6684448 | biostudies-literature
UnknownA specific subdomain in phi29 DNA polymerase confers both processivity and strand-displacement capacity.
Not available
S-EPMC1088371 | biostudies-literature
TranscriptomicsExpression data in Arabidopsis axe1-5 and met1-3 mutants.
We applied the tiling arrays to study the Arabidopsis whole-genome transcriptome in Arabidopsis axe1-5 and met1-3 mutants. Fifteen-day-old Arabidopsis plants grown on the agar plates were harvested. The total RNA was prepared from 15-day-old Arabidopsis plants (axe1-5 (hda6 mutant), DR5 (parental li...
ORGANISM(S): Arabidopsis thaliana 
2011-05-15 | E-GEOD-23950 | biostudies-arrayexpress
TranscriptomicsStructural and functional characterization of the N-terminus of Schizosaccharomyces pombe Cwf10
The spliceosome is a dynamic macromolecular machine that catalyzes the removal of introns from pre-mRNA to make mature message. Schizosaccharomyces pombe Cwf10 (homolog Saccharomyces cerevisiae Snu114 and of Human U5-116K), an integral member of the U5 snRNP, is a GTPase that shares sequence homolog...
ORGANISM(S): Schizosaccharomyces pombe 
2013-09-25 | E-GEOD-47573 | biostudies-arrayexpress
TranscriptomicsInfluence of oxygen limitation, absence of the cytochrome bc1 complex and low pH on global gene expression in Gluconobacter oxydans 621H using DNA microarray technology
The genome-wide transcriptional responses of the strictly aerobic -proteobacterium Gluconobacter oxydans 621H to oxygen limitation, to the absence of the cytochrome bc1 complex, and to low pH were studied using DNA microarray analyses. Oxygen limitation caused expression changes of 486 genes, repres...
ORGANISM(S): Gluconobacter oxydans 621H 
2012-03-23 | E-GEOD-34294 | biostudies-arrayexpress
TranscriptomicsAnalysis of colorectal tissue from APC- and MYH-associated polyposis patients
Expression profiling is a well established tool for the genome-wide analysis of the transcriptional activity of human neoplasia. However, the high sensitivity of this approach combined with the well-known cellular and molecular heterogeneity of cancer often result in extremely complex and extended e...
ORGANISM(S): Homo sapiens 
2008-04-01 | E-GEOD-9689 | biostudies-arrayexpress
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