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TranscriptomicsTranscriptional profiling of Mycobacterium tuberculosis exposed to antibiotics and drug combinations in broth culture.
We profiled Mtb transcriptional response to a range of different antibiotic drug exposures in 7H9 broth culture by RNA-seq. Compound abbreviations: (EMB = ethambutol, BTZ = BTZ043, TYL = tyloxapol). We also hypothesized that an improved Mtb TRN could be inferred using a large, diverse compendium of ...
ORGANISM(S): Mycobacterium tuberculosis 
2025-03-21 | GSE292636 | GEO
TranscriptomicsTranscriptional profiling of Mycobacterium tuberculosis exposed to proton pump inhibitor treatment in broth culture.
We hypothesized that an improved Mtb TRN could be inferred using a large, diverse compendium of RNA-seq data and therefore sought to supplement the existing repository of Mtb expression data available on SRA with additional conditions that could inform on Mtb's underlying regulatory programs. We pro...
ORGANISM(S): Mycobacterium tuberculosis 
2025-03-19 | GSE292408 | GEO
ProteomicsStress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation
The fidelity of translation is crucial in prokaryotes and for the nuclear-encoded proteins of eukaryotes, however little is known about the role of mistranslation in mitochondria and its effects on metabolism. We generated yeast and mouse models with error-prone and hyperaccurate mitochondrial trans...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-08 | PXD015456 | Pride
Oxidative phosphorylation Mitochondrial ribosome  mrps12 Stress response abbreviations used: mitoribosome Mitochondrial ribosomal protein of the small subunit 12  oxphos Mitochondria Metabolism Protein synthesis 
TranscriptomicsTranscriptional profiling of Mycobacterium tuberculosis exposed to antibiotic treatment in broth culture.
We profiled Mtb transcriptional response to a range of different antibiotic drug exposures in 7H9 broth culture by RNA-seq. Compound abbreviations: (AMK = amikacin, BDQ = bedaquiline, CPF = ciprofloxacin, LVF = levofloxacin, MXF = moxifloxacin, CFZ = clofazimine, PA824 = pretomanid, RPE = rifapentin...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2025-03-19 | GSE292332 | GEO
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