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MetabolomicsSusceptibility to febrile malaria is associated with an inflammatory gut microbiome

Malaria is a major public health problem, but many of the factors underlying the pathogenesis of this disease are not well understood. Here, we demonstrate in Malian children that susceptibility to febrile malaria following infection with Plasmodium falciparum is associated with the comp...

2024-09-13 | MTBLS2247 | MetaboLights
MetabolomicsLeucine degradation metabolite ratio as a measure of meropenem susceptibility in carbapenem-resistant Klebsiella pneumoniae

Rapid detection of carbapenem-resistant Klebsiella pneumoniae (CRKP) is essential for effective clinical management and surveillance. This study investigated volatile organic compounds (VOCs) as phenotypic biomarkers of carbapenem resistance, with the goal of developing a translationally...

2026-06-09 | MTBLS13539 | MetaboLights
MetabolomicsOPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response

Ferroptosis, an iron-dependent form of nonapoptotic cell death mediated by lipid peroxidation, has been implicated in the pathogenesis of multiple diseases. Subcellular organelles play pivotal roles in the regulation of ferroptosis, but the mechanisms underlying the contributions of the mitochond...

2025-07-14 | MTBLS10544 | MetaboLights
TranscriptomicsSex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress
Depression and anxiety disorders are more prevalent in females, but the majority of research in animal models, the first step in finding new treatments, has focused predominantly on males. Here we report that exposure to subchronic variable stress (SCVS) induces depression-associated behaviors in fe...
ORGANISM(S): Mus musculus 
2016-08-04 | E-GEOD-85136 | biostudies-arrayexpress
MetabolomicsUntargeted Plasma Lipidomics Identifies Oxidative Stress and Inflammation Signatures Associated with Recurrent Leg Ulcer Status in Sickle Cell Disease

Leg ulcers are among the most burdensome complications of sickle cell disease (SCD), yet the molecular determinants underlying ulcer susceptibility and recurrence remain incompletely characterized. We performed untargeted plasma lipidomics by LC–MS in 129 individuals with SCD from the REDS-III Br...

2025-12-19 | MTBLS13538 | MetaboLights
TranscriptomicsTranscription profiling of immortalized B cells from unrelated individuals and twins undergoing ER stress
The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) results in the condition called “ER stress” which induces the unfolded protein response (UPR) which is a complex cellular process that includes changes in expression of many genes. Failure to restore homeostasis...
ORGANISM(S): Homo sapiens 
2010-04-08 | E-GEOD-19519 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of chicken liver after alpha- and gamma-tocopherol supplementation in case of increased oxidative stress susceptibility
A 30-day nutritional trial in broiler chickens (Ross 308) was conducted to investigate how specific forms of vitamin E (α- and γ-tocopherol) and their combination impact liver gene expression when oxidative susceptibility of the organism is induced by high n-3 polyunsaturated fatty acids (PUFA) in...
ORGANISM(S): Gallus gallus 
2017-02-28 | E-MTAB-4507 | biostudies-arrayexpress
MetabolomicsThe impact of genetic stress by ATGL deficiency on the lipidome of lipid droplets from murine hepatocytes
We showed earlier that nutritional stress like starvation or high fat diet resulted in phenotypic changes in the lipidomes of hepatocyte lipid droplets (LDs), representative for the pathophysiological status of the mouse model. Here we extend our former study by adding genetic stress due to knock-ou...
2014-08-19 | MTBLS81 | MetaboLights
MetabolomicsPeroxin Pex8 couples stress responses, antifungal tolerance and virulence regulation in Candida albicans

Candida albicans, a World Health Organization critical-priority fungal pathogen, represents the predominant cause of candidemia. Therapeutic failure is sometimes driven by antifungal tolerance, a phenotype distinct from resistance, whose underlying mechanisms remain incompletely defined....

2026-03-12 | MTBLS13170 | MetaboLights
MetabolomicsRelationship Between Vitamin D Levels and Psychological Stress-Induced Asthma Prevalence: An Untargeted Metabolomics Study Combined with the NHANES Database
The incidence of psychological stress–induced asthma has been increasing annually, and numerous previous studies have shown that vitamin D is associated with the development of asthma as well as anxiety and depression. However, no studies to date have clarified the relationship between vitamin D and...
2026-04-16 | MTBLS14208 | MetaboLights
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