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MetabolomicsOptimised LC-MS Metabolomic Profiling Reveals Emergent Changes to Monocyte Metabolism in Response to Lipopolysaccharide
Immunometabolism examines the links between immune cell function and metabolism. Dysregulation of immune cell metabolism is now an established feature of innate immune cell activation. Advances in liquid chromatography mass spectrometry (LC-MS) technologies have allowed discovery of unique insights ...
2025-11-17 | MTBLS6730 | MetaboLights
MetabolomicsMulti-dimensional leaf phenotypes reflect root system genotype in grafted grapevine over the growing season

BACKGROUND: Modern biological approaches generate volumes of multi-dimensional data, offering unprecedented opportunities to address biological questions previously beyond reach owing to small or subtle effects. A fundamental question in plant biology is the extent to which below...

2022-01-07 | MTBLS2831 | MetaboLights
MetabolomicsIntegrating genomics and multi‐platform metabolomics enables metabolite QTL detection in breeding‐relevant apple germplasm
Apple (Malus × domestica) has commercial and nutritional value, but breeding constraints of tree crops limit varietal improvement. Marker-assisted selection minimizes these drawbacks, but breeders lack applications for targeting fruit phytochemicals. To understand genotype-phytochemical associations...
2021-09-21 | MTBLS2327 | MetaboLights
TranscriptomicsTranscription profiling of skin samples from atopic dermatitis patients before and after treatment with cyclosporine A
After 2 and 12 weeks of treatment, we observed significant reductions of 51% and 72%, respectively, in SCORAD scores. Clinical improvements were associated with significant gene expression changes in lesional but also nonlesional skin, particularly reductions in levels of TH2-, TH22-, and some TH17-...
ORGANISM(S): Homo sapiens 
2014-06-17 | E-GEOD-58558 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of acute and chronic atopic dermatitis compared to normal skin
Atopic dermatitis (AD) is a common disease, with an increasing prevalence. The primary pathogenesis of the disease is still elusive, resulting in lack of specific treatments. The prevailing view is that AD is a biphasic, T-cell polarized disease, with Th2 predominating acute AD, and a switch to Th1 ...
ORGANISM(S): Homo sapiens 
2012-09-21 | E-GEOD-36842 | biostudies-arrayexpress
TranscriptomicsSymmetrical dose-dependent DNA methylation profiles in children with deletion or duplication of chromosome 7q11.23
Genome wide DNA methylation in blood derived DNA from individuals with deletion or duplication of 7q11.23 Bisulfite converted DNA was hybridized onto the Illumina Infinium HumanMethylation450 BeadChip array
ORGANISM(S): Homo sapiens 
2015-07-09 | E-GEOD-66552 | biostudies-arrayexpress
UnknownTryptophan metabolites profile predict remission with dietary therapy in pediatric Crohn's disease.
Not available
S-EPMC11863242 | biostudies-literature
TranscriptomicsTranscription profiling of Pseudomonas putida PP3546 mutant
Transcription profiling of Pseudomonas putida PP3546 mutant
ORGANISM(S): Pseudomonas putida 
2013-04-02 | E-MEXP-3655 | biostudies-arrayexpress
UnknownComprehensive functional testing in fibroblasts has strong utility to diagnose mitochondrial disease
Not available
S-SCDT-10_1038-S44321-026-00497-3 | biostudies-other
TranscriptomicsRNA-Seq of Escherichia coli Nissle 1917 strains modified to produce different amounts of the bacteriocin microcin C
A popular strategy for enhancing the antibacterial properties of probiotic bacteria is to retrofit them with the ability to overproduce heterologous bacteriocins. This is often achieved from strong, non-native promoters. How the dysregulated overproduction of heterologous bacteriocins affects the fi...
ORGANISM(S): Escherichia coli 
2023-06-30 | E-MTAB-13078 | biostudies-arrayexpress
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