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ProteomicsSyntaxin5’s flexibility in SNARE pairing supports Golgi functions
The intracellular transport system is an evolutionally conserved, essential, and highly regulated network of organelles and small transport carriers that traffic protein and lipid cargoes within the cell. The Conserved Oligomeric Golgi (COG) complex is the major Golgi Multisubunit Tethering Complex....
ORGANISM(S): Homo sapiens (Human) 
2023-06-26 | PXD036741 | Pride
Membrane trafficking Golgi Bet1l Vti1b Snap29 Gor1 Gosr2 Cog Snares Stx5 Ykt6 
ProteomicsFunctional Dissection of the Retrograde Shiga Toxin Trafficking Inhibitor Retro-2
The retrograde transport inhibitor Retro-2 has a protective effect on cells and in mice against Shiga-like toxins and ricin. Retro-2 causes toxin accumulation in early endosomes, and the relocalization of the Golgi SNARE protein syntaxin-5 to the endoplasmic reticulum. The molecular mechanisms by wh...
ORGANISM(S): Homo sapiens (Human) 
2020-02-24 | PXD015642 | Pride
Er exit site Sec16a Retro-2 Syntaxin5 Shiga toxin Mass spectrometry Retrograde transport 
ProteomicsSyntaxin 5 determines Weibel-Palade body size and Von Willebrand factor secretion by controlling Golgi architecture
Abstract Von Willebrand factor (VWF) is a multimeric hemostatic protein primarily synthesized in endothelial cells (ECs). VWF is stored in endothelial storage organelles, the Weibel-Palade bodies (WPBs), whose biogenesis strongly depends on VWF anterograde trafficking and Golgi architecture. Elongat...
ORGANISM(S): Homo sapiens (Human) 
2022-01-27 | PXD027516 | Pride
Human Endothelial cells Weibel-palade bodies Von willebrand factor 
UnknownCongenital disorder of glycosylation caused by starting site-specific variant in syntaxin-5.
Not available
S-EPMC8553859 | biostudies-literature
UnknownSyntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2.
Not available
S-EPMC2572927 | biostudies-literature
UnknownSyntaxin-5's flexibility in SNARE pairing supports Golgi functions.
Not available
S-EPMC10330844 | biostudies-literature
UnknownPlasma membrane cholesterol trafficking in steroidogenesis.
Not available
S-EPMC6988844 | biostudies-literature
UnknownMice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo.
Not available
S-EPMC5175141 | biostudies-literature
UnknownCOPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways.
Not available
S-EPMC6212795 | biostudies-literature
UnknownCOG complexes form spatial landmarks for distinct SNARE complexes.
Not available
S-EPMC3595136 | biostudies-literature
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