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GenomicsMechanisms of Ikaros Tumor Suppression with HDAC1 through distinct histone markers in Pre-B ALL Leukemia
Ikaros functions as a master regulator of lymphocyte differentiation and a tumor suppressor. Ikaros binds DNA and regulates gene expression by chromatin remodeling. Mechanisms of Ikaros-mediated tumor suppression are unknown. Here we examined genome-wide occupancy of Ikaros and histone deacetylase 1...
ORGANISM(S): Homo sapiens 
2015-11-03 | E-GEOD-44217 | biostudies-arrayexpress
TranscriptomicsDisruption of Ttll5/Stamp gene (Tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2 associated modulatory protein gene) in male mice causes sperm malformation and infertility
Tubulin tyrosine ligase-like family member 5 (TTLL5/STAMP) has multiple activities in cells. TTLL5 is one of 13 TTLLs, has polyglutamylation activity, augments the activity of p160 coactivators (SRC-1 and TIF2) in glucocorticoid receptor-regulated gene induction and repression, and displays steroid-...
ORGANISM(S): Mus musculus 
2013-03-28 | E-GEOD-45546 | biostudies-arrayexpress
ProteomicsUsing proteomics and transcriptomics to explore the potential gene regulatory network of immune checkpoint inhibitors-related myocarditis
Immune checkpoint inhibitor-related myocarditis is the deadliest complication of immunotherapy. However, the underlying pathophysiological mechanisms of its occurrence and development remain unclear. Due to the long-term lack of effective early diagnosis and treatment options, it is of great signifi...
ORGANISM(S): Homo Sapiens 
2023-02-02 | PXD039793 |
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