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GenomicsPrep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis.
Prep1 is a tumor-suppressor, whereas Meis1 is an oncogene. We show that to perform these activities in MEFs both proteins competitively hetero-dimerize with Pbx1. Meis1 alone transforms Prep1-deficient fibroblasts while Prep1 overexpression inhibits Meis1 tumorigenicity. Pbx1 can therefore alternati...
ORGANISM(S): Mus musculus 
2014-03-05 | E-GEOD-54221 | biostudies-arrayexpress
GenomicsPrep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis [hP]
Prep1 is a tumor-suppressor, whereas Meis1 is an oncogene. We show that to perform these activities in MEFs both proteins competitively hetero-dimerize with Pbx1. Meis1 alone transforms Prep1-deficient fibroblasts while Prep1 overexpression inhibits Meis1 tumorigenicity. Pbx1 can therefore alternati...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-58802 | biostudies-arrayexpress
TranscriptomicsMeis1 induces and Prep1 suppresses tumors by exploiting low affinity AP1 binding sites.
We have defined the tumor and tumor suppressor signature for Meis1 and Prep1 (pKnox1), respectively, using ChIP-seq and RNA-seq in a cell system in which tumor suppressor Prep1 and oncogene Meis1 compete for tumorigenesis [GSE54221; GSE58802]. In this paper we report that the number of Meis1 or Prep...
ORGANISM(S): Mus musculus 
2016-06-25 | E-GEOD-58818 | biostudies-arrayexpress
UnknownQuiescent Cells Actively Replenish CENP-A Nucleosomes to Maintain Centromere Identity and Proliferative Potential.
Not available
S-EPMC6783363 | biostudies-literature
ProteomicsLabel-free quantification of 3D MCF10A cell culture proteome (DIA)
Global shotgun proteomic analysis using data independent acquisition (DIA) and Spectronaut analysis on the input cell lysates before the enrichment step in proximity labeling experiments, specifically MCF10A cells stably expressing miniTurbo-BAD in 3D with biotin treatment (n=4)
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-21 | MSV000094825 | MassIVE
UnknownInterleukin-2 superkines by computational design.
Not available
S-EPMC8944926 | biostudies-literature
ProteomicsBAD BioID in 2D MCF10A cell culture
BioID proximity labeling experiment on Bcl2-associated agonist of cell death (BAD) using BAD-miniTurbo stable cell line in MCF10A, 2D cell culture. Sample: BAD-turbo-biotin; controls: BAD-biotin, turbo-biotin, BAD-turbo (n=3).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-10 | MSV000093357 | MassIVE
GenomicsTherapeutic Resistance to PI3K-alpha Inhibitors
We have studied the tumor genomic evolution in a patient with metastatic breast cancer bearing an activating PIK3CA mutation. The patient was treated with the PI3Kα inhibitor BYL719 and achieved a lasting clinical response on BYL719, but eventually progressed to treatment and died shortly thereafter...
EGAS00001000991 | EGA
TranscriptomicsSkeletal muscle derived stem cell implantation therapy in a rat model of erectile dysfunction
Muscle derived stem cells were isolated from Zucker Obese rats and implanted into the penises of diabetic rats. Rats were analyzed for potential therapeutic benefit. The skeletal muscle derived stem cells were grown in culture and analyzed by DNA microarray analysis for gene expression. RNA was isol...
ORGANISM(S): Rattus norvegicus 
2016-09-07 | E-GEOD-72834 | biostudies-arrayexpress
TranscriptomicsIdentification of cis-eQTLs in six immune cell types CD4, CD8, CD14,CD15, CD19, PLA and ileal, colonic and rectal biopsies in 323 healthy European individuals (CEDAR cohort).
Transcriptome in 6 immune cell types and 3 colonic biopsis from 323 individuals in order to perform cis-eQTL analysis. Identification of regulatory modules across genes and tissues on the basis of correlated SNPs in expression associated patterns (EAPs). Integration of cis-eQTLs regulatory modules w...
ORGANISM(S): Homo sapiens 
2018-04-28 | E-MTAB-6667 | biostudies-arrayexpress
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