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GenomicsDeep sequencing of the murine Igh repertoire reveals complex regulation of non-random V gene rearrangement frequencies
A diverse antibody repertoire is formed through the rearrangement of V, D, and J segments at the immunoglobulin heavy chain (Igh) loci. The C57BL/6 murine Igh locus has over 100 functional VH gene segments that can recombine to a rearranged DJH. While the non-random usage of VH genes is well documen...
ORGANISM(S): Mus musculus 
2013-08-05 | E-GEOD-47766 | biostudies-arrayexpress
TranscriptomicsThe Rpd3 Core Complex is a Chromatin Stabilization Module
The S. cerevisiae Rpd3 large (Rpd3L) and small (Rpd3S) histone deacetylase (HDAC) complexes are prototypes for understanding transcriptional repression in eukaryotes [1]. The current view is that they function by deacetylating chromatin, thereby limiting accessibility of transcriptional factors to t...
ORGANISM(S): Saccharomyces cerevisiae 
2012-01-01 | E-GEOD-33829 | biostudies-arrayexpress
GenomicsThe PIAS-like coactivator Zmiz1 directly and selectively coregulates Notch1 in T-cell development and leukemia [ChIP-Seq]
The most recurrently mutated oncogene in T-cell acute lymphoblastic leukemia (T-ALL) is NOTCH1. The core Notch complex consists of an ICN protein, a Maml cofactor, and the DNA binding factor Rbpj. The known direct cofactors of Notch appear to act nonselectively, homogeneously driving Notch gene expr...
ORGANISM(S): Mus musculus 
2015-10-28 | E-GEOD-66146 | biostudies-arrayexpress
TranscriptomicsThe PIAS-like coactivator Zmiz1 directly and selectively coregulates Notch1 in T-cell development and leukemia [RNA-Seq]
The most recurrently mutated oncogene in T-cell acute lymphoblastic leukemia (T-ALL) is NOTCH1. The core Notch complex consists of an ICN protein, a Maml cofactor, and the DNA binding factor Rbpj. The known direct cofactors of Notch appear to act nonselectively, homogeneously driving Notch gene expr...
ORGANISM(S): Mus musculus 
2015-10-28 | E-GEOD-66145 | biostudies-arrayexpress
TranscriptomicsGene expression and genotype in normal heart
Genome-wide association studies have identified a small region at chromosome 9p21.3 strongly associated with coronary heart disease risk. The region contains no protein-coding genes and the mechanism underlying its association with heart disease is unknown. We investigated associations between rs133...
ORGANISM(S): Homo sapiens 
2012-07-03 | E-GEOD-22253 | biostudies-arrayexpress
TranscriptomicsMEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors, despite transcriptional feedback onto ERK.
Neurofibromatosis Type 1 (NF1) patients develop benign neurofibromas and malignant peripheral nerve sheath tumors (MPNST). These incurable peripheral nerve tumors result from loss of NF1 tumor suppressor gene function, causing hyperactive Ras signaling. Activated Ras controls numerous downstream eff...
ORGANISM(S): Mus musculus 
2012-12-28 | E-GEOD-41747 | biostudies-arrayexpress
TranscriptomicsProspective Identification, Isolation, and Profiling of a Telomerase-Expressing Subpopulation of Human Neural Stem Cells, using sox2 Enhancer-Directed Fluorescence-Activated Cell Sorting
Sox2 is expressed by neural stem and progenitor cells, and a sox2 enhancer identifies these cells in the forebrains of both fetal and adult transgenic mouse reporters. We found that an adenovirus encoding EGFP placed under the regulatory control of a 0.4 kb sox2 core enhancer selectively identified ...
ORGANISM(S): Homo sapiens 
2011-02-25 | E-GEOD-27505 | biostudies-arrayexpress
UnknownRecombinant manufacturing of multispecies biolubricants.
Not available
S-EPMC11092771 | biostudies-literature
UnknownMicroRNA cargo in neuron-derived vesicles as peripheral biomarkers of brain insulin dysregulation.
Not available
S-EPMC12441806 | biostudies-literature
UnknownCD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma.
Not available
S-EPMC10905524 | biostudies-literature
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