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TranscriptomicsT cell UTX promotes Tfh-mediated clearance of persistent virus infection
Epigenetic changes, including histone methylation, control T cell differentiation and memory formation, though the enzymes that mediate these processes are not clear. We show that UTX, a histone H3 lysine 27 (H3K27) demethylase, promotes the generation of T follicular helper (Tfh) cells, a CD4+ T ce...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-64969 | biostudies-arrayexpress
UnknownGenome-Wide CRISPR Screen Identifies KEAP1 Perturbation as a Vulnerability of ARID1A-Deficient Cells.
Not available
S-EPMC11394604 | biostudies-literature
UnknownContribution of excision repair cross-complementing group 1 genotypes to triple negative breast cancer risk.
Not available
S-EPMC6086438 | biostudies-literature
GenomicsChIP-Seq of ORC2 bound to third instar salivary gland DNA in WT and mutant Drosophila, analyzed by Illumina sequencing
We analyzed ORC2 ChIP-Seq from hand dissected salivary glands of wandering third instar larvae from OrR or SuUR Drosophila. Goals were to ascertain the difference in binding profile between salivary glands expressing and not expressing the Supressor of UnderReplication protein. One replicate is incl...
ORGANISM(S): Drosophila melanogaster 
2011-10-18 | E-GEOD-31899 | biostudies-arrayexpress
UnknownSerum urate and cardiovascular events in the DCCT/EDIC study.
Not available
S-EPMC8271014 | biostudies-literature
UnknownIn vivo CRISPR screens identify a dual function of MEN1 in regulating tumor-microenvironment interactions.
Not available
S-EPMC11387198 | biostudies-literature
TranscriptomicsHeterochromatin protein 1 secures survival and transmission of malaria parasites
The malaria parasite Plasmodium falciparum relies on clonally variant gene expression in order to escape immune recognition and secure continuous proliferation during blood stage infection. Here, we studied the role of heterochromatin protein 1 (HP1), an evolutionary conserved regulator of heritable...
ORGANISM(S): Plasmodium falciparum 3D7 
2014-07-09 | E-GEOD-53176 | biostudies-arrayexpress
UnknownPath integration selectively predicts midlife risk of Alzheimer's disease.
Not available
S-EPMC9915680 | biostudies-literature
UnknownRoutine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials.
Not available
S-EPMC3335021 | biostudies-literature
TranscriptomicsExpression profile of third instar larval fat body and midgut tissues
We use mRNA-seq to transcriptionally profile larval fat body and midgut tissues from Drosophila third instar larvae. These data provide insights into tissue physiology and can be used to identify tissue specific transcripts. Fat bodies from wandering third instar larvae were dissected from ~50 male ...
ORGANISM(S): Drosophila melanogaster 
2010-11-02 | E-GEOD-25025 | biostudies-arrayexpress
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