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GenomicsGenome-wide binding map of the HIV Tat protein to the human genome (ChIP-Seq)
The HIV-1 Trans-Activator of Transcription (Tat) protein binds to multiple host cellular factors and greatly enhances the level of transcription of the HIV genome. Here, we report the genome-wide binding map of Tat to the human genome in Jurkat T cells (Jurkat-Tat cells) using chromatin immunopreci...
ORGANISM(S): Homo sapiens 
2011-11-06 | E-GEOD-30738 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding map of the HIV Tat protein to the human genome (gene expression)
The HIV-1 Trans-Activator of Transcription (Tat) protein binds to multiple host cellular factors and greatly enhances the level of transcription of the HIV genome. Here, we report the genome-wide binding map of Tat to the human genome in Jurkat T cells (Jurkat-Tat cells) using chromatin immunopreci...
ORGANISM(S): Homo sapiens 
2011-11-06 | E-GEOD-30734 | biostudies-arrayexpress
TranscriptomicsA unique epigenetic signature is associated with active DNA replication loci in human embryonic stem cells
The cellular epigenetic landscape changes as pluripotent stem cells differentiate to somatic cells or when differentiated cells transform to a cancerous state. These epigenetic changes are commonly correlated with differences in gene expression. Whether active DNA replication is also associated with...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-GEOD-43152 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding map of the HIV Tat protein to the human genome (ChIP-chip)
The HIV-1 Trans-Activator of Transcription (Tat) protein binds to multiple host cellular factors and greatly enhances the level of transcription of the HIV genome. Here, we report the genome-wide binding map of Tat to the human genome in Jurkat T cells (Jurkat-Tat cells) using chromatin immunopreci...
ORGANISM(S): Homo sapiens 
2011-11-06 | E-GEOD-30736 | biostudies-arrayexpress
GenomicsCBP/P300 Function in Repression as well as Activation Regulated by Adenovirus Small E1A [RB1_ChIP]
Oncogenic transformation by adenovirus small e1a depends on simultaneous interactions with P300/CBP and RB proteins. To understand why, experiments with structure-based e1a mutants were analyzed with RNA- and ChIP-seq. The results indicate that e1a displaces RBs from E2F activation domains and, by p...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-59689 | biostudies-arrayexpress
GenomicsCBP/P300 Function in Repression as well as Activation Regulated by Adenovirus Small E1A [IMR90_Input]
Oncogenic transformation by adenovirus small e1a depends on simultaneous interactions with P300/CBP and RB proteins. To understand why, experiments with structure-based e1a mutants were analyzed with RNA- and ChIP-seq. The results indicate that e1a displaces RBs from E2F activation domains and, by p...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-59692 | biostudies-arrayexpress
GenomicsCBP/P300 Function in Repression as well as Activation Regulated by Adenovirus Small E1A [H3k27ac_ChIP]
Oncogenic transformation by adenovirus small e1a depends on simultaneous interactions with P300/CBP and RB proteins. To understand why, experiments with structure-based e1a mutants were analyzed with RNA- and ChIP-seq. The results indicate that e1a displaces RBs from E2F activation domains and, by p...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-59680 | biostudies-arrayexpress
GenomicsCBP/P300 Function in Repression as well as Activation Regulated by Adenovirus Small E1A [p300_ChIP]
Oncogenic transformation by adenovirus small e1a depends on simultaneous interactions with P300/CBP and RB proteins. To understand why, experiments with structure-based e1a mutants were analyzed with RNA- and ChIP-seq. The results indicate that e1a displaces RBs from E2F activation domains and, by p...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-59681 | biostudies-arrayexpress
GenomicsCBP/P300 Function in Repression as well as Activation Regulated by Adenovirus Small E1A [RB1_ChIP_2]
Oncogenic transformation by adenovirus small e1a depends on simultaneous interactions with P300/CBP and RB proteins. To understand why, experiments with structure-based e1a mutants were analyzed with RNA- and ChIP-seq. The results indicate that e1a displaces RBs from E2F activation domains and, by p...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-59690 | biostudies-arrayexpress
GenomicsCBP/P300 Function in Repression as well as Activation Regulated by Adenovirus Small E1A [Pol2_ChIP]
Oncogenic transformation by adenovirus small e1a depends on simultaneous interactions with P300/CBP and RB proteins. To understand why, experiments with structure-based e1a mutants were analyzed with RNA- and ChIP-seq. The results indicate that e1a displaces RBs from E2F activation domains and, by p...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-59691 | biostudies-arrayexpress
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