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TranscriptomicsThe identification of differentially expressed genes between animal and vegetal blastomeres in Xenopus laevis
To identify asymmetrically localized maternal mRNAs along the animal-vegetal axis in cleavage Xenopus embryos, we isolated animal and vegetal blastomeres at 8-cell stage, extracted the maternal mRNA respectively and analyzed them by RNA-seq technology. We identified 43 maternal transcripts significa...
ORGANISM(S): Xenopus laevis 
2015-05-19 | E-GEOD-68972 | biostudies-arrayexpress
TranscriptomicsOpposing roles for the lncRNA Haunt and its genomic locus in regulating HOXA gene activation during embryonic stem cell differentiation
Long noncoding RNAs (lncRNAs) have been implicated in controlling various aspects of embryonic stem cell (ESC) biology, although the functions of specific lncRNAs, and the molecular mechanisms through which they act, remain unclear. Here, we demonstrate discrete and opposing roles for the lncRNA tra...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-58514 | biostudies-arrayexpress
ProteomicsA Pandas complex adapted for piRNA-guided transposon silencing and heterochromatin formation
dNxf2 directly interacts with dNxf1 to compete with its binding to NPC
ORGANISM(S): Drosophila Melanogaster 
2019-08-01 | PXD014884 |
ProteomicsA Pandas complex adapted for piRNA-guided transposon silencing and heterochromatin formation, Panx-IP-MS
The repression of transposons by the Piwi-interacting RNA (piRNA) pathway is essential to protect animal germ cells. In Drosophila ovaries, Panoramix (Panx) enforces transcriptional silencing by binding to the target-engaged Piwi-piRNA complex, although the precise mechanisms by which this occurs re...
ORGANISM(S): Drosophila Melanogaster 
2019-08-06 | PXD014926 |
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