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ProteomicsTandem mass tag-based proteomic profiling of drainage fluid
Anastomotic leakage (AL), one of the most severe complications in rectal surgery, is often diagnosed late because of the low specificity of clinical symptoms and limitations of current clinical investigations. Identification of patients with early AL remains challenging. Here, we explored the protei...
ORGANISM(S): Homo Sapiens 
PXD043410 |
ProteomicsUV‑ARTP compound mutagenesis breeding improves macrolactin production of Bacillus siamensis and reveals metabolism changes by proteomic
Macrolactin is a compound with complex macrolide structure which only be obtained through microbiological fermentation now. It has excellent antifungal, antibacterial and antitumor activity. In this study, Bacillus siamensis YB304 was used as the research object, and a mutant Mut-K53 with stable gen...
ORGANISM(S): Bacillus Siamensis 
PXD043264 |
ProteomicsBRAF inhibitors enhance erythropoiesis and treat anemia through paradoxical activation of MAPK
Erythropoiesis is a crucial part in hematopoietic system, while facing disruptions from various diseases conditions. Anemia and blood shortages has become global challenges, with current finite pharmacological options like EPO or glucocorticoids having limitations, especially in genetic anemias like...
ORGANISM(S): Homo Sapiens 
PXD055730 |
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