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GenomicsWhole genome sequencing of TF-AID-mutagenized flies
In this study, we stably expressed TF-AID in the germline of Drosophila melanogaster to induce mutations around specific transcription factor binding sites across the genome. To identify the mutations, we sequenced: (1) individual flies from the TF-AID-expressing populations, sampled across generati...
ORGANISM(S): Drosophila melanogaster 
2025-01-23 | E-MTAB-13796 | biostudies-arrayexpress
GenomicsWhole genome sequencing of experimentally evolved D. melanogaster populations with 4xBicoid
EMS-mutagenized D. melanogaster populations with 4xbicoid were sequenced at the 1st, 3rd, 7th, 9th and 15th generation to analyze genomic changes during experimental evolution. Non-mutagenized populations were sequenced in parallel, representing standing variations.
ORGANISM(S): Drosophila melanogaster 
2023-05-16 | E-MTAB-11768 | biostudies-arrayexpress
TranscriptomicsHigh-resolution genetic analysis of cancer cell lines with near normal karyotypes
Cancer development is associated with multiple genetic alterations and genomic instability either at the chromosomal or base pair level is generally thought to underlie these changes. However, it is still unknown whether genetic instability is absolutely required for tumorigenesis. Here we investig...
ORGANISM(S): Homo sapiens 
2008-03-14 | E-GEOD-8649 | biostudies-arrayexpress
TranscriptomicsPulmonary alveolar macrophages (PAMs) of Tongcheng piglets response to HP-PRRSV infection in vivo
Porcine reproductive and respiratory syndrome (PRRS), caused by PRRS virus (PRRSV), is the most economically important disease in pig populations. Lung damage is one major pathological condition following PRRSV infection, often leading to animal death. In vivo, PRRSV productive infection occurs pred...
ORGANISM(S): Sus scrofa 
2012-06-30 | E-GEOD-22782 | biostudies-arrayexpress
TranscriptomicsInvestigation of extra-telomeric effects of hTERT in neoplastic transformation of IMR90 cells
The complexity and heterogeneity of cancer cells are under-represented by the current experimental models which revolve around primary tumor cells, cancer cell lines, and rodent models. We used the transformed cell model in our studies. IMR90 and BJ fibroblast cells were transformed by three oncogen...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-24097 | biostudies-arrayexpress
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