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MetabolomicsShort-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

INTRODUCTION: Bariatric surgery is known to be the most effective treatment for weight loss in obese patients and for the rapid remission of obesity-related comorbidities. These short-term improvements result from not only limited digestion or absorption but also dynamic changes ...

2022-03-17 | MTBLS2472 | MetaboLights
UnknownTherapeutic Effects of Modified Si-Miao-Yong-An Decoction in the Treatment of Rat Myocardial Ischemia/Reperfusion Injury.
Not available
S-EPMC9192308 | biostudies-literature
ProteomicsSite-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins using High-Resolution Mass Spectrometry
The global pandemic of severe acute pneumonia syndrome (COVID-19) caused by SARS-CoV-2 urgently calls for prevention and intervention strategies. The densely glycosylated spike (S) protein highly exposed on the viral surface is a determinant for virus binding and invasion into host cells as well as ...
ORGANISM(S): Homo sapiens (Human) 
2020-10-05 | PXD018506 | Pride
Sars-cov-2  spike protein  n-glycosylation  mass spectrometry 
ProteomicsComprehensive human plasma N-glycoproteome profiling based on EThcD-sceHCD-MS/MS
N-glycoproteins are involved in various biological processes. More than one-third of plasma tumor protein biomarkers approved by the Food and Drug Administration (FDA) are glycoproteins which would enhance the specificity and/or sensitivity of cancer diagnosis. Therefore, the characterization of pla...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD030622 | Pride
Mass spectrometry  human plasma  n-glycoproteomics  combinatorial peptide ligands library  ethcd-scehcd 
ProteomicsGlyco-CPLL: an integrated method for in-depth and comprehensive N-glycoproteome profiling of human plasma
N-glycoproteins are involved in various biological processes. Certain distinctive glycoforms on specific glycoproteins enhance the specificity and/or sensitivity of cancer diagnosis. Therefore, the characterization of plasma N-glycoproteome is essential for new biomarker discovery. Absence of suitab...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD016428 | Pride
Mass spectrometry  papillary thyroid carcinoma  n-glycoproteomics  combinatorial peptide ligands library 
ProteomicsProteomic Landscape of Human Spermatozoa: Optimized Extraction Method and Application
Human spermatozoa proteomics exposed to some physical, biological or chemical stressors is being explored. However, there is a lack of systematic comparative study on protein extraction methods to achieve in-depth coverage. Meanwhile, it is not clear if antibiotics can regulate proteins to affect sp...
ORGANISM(S): Homo sapiens (Human) 
2022-12-18 | PXD036023 | Pride
Spermatozoa Extraction method Antibiotic Mass spectrometry Proteomics 
ProteomicsComparative glycoproteomic profiling of human body fluid between healthy controls and patients with papillary thyroid carcinoma
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer among women worldwide. It is confirmed mainly by fine-needle aspiration biopsy (FNAB), an invasive diagnostic method. The key proteins responsible for thyroid hormone biosynthesis are glycosylated. Changes in site-specific g...
ORGANISM(S): Homo sapiens (Human) 
2019-12-09 | PXD015360 | Pride
Biomarker  mass spectrometry  site-specific n-glycopeptide  thyroid cancer 
ProteomicsEThcD-sceHCD-MS/MS-based Clinical N-glycoproteomics
Site-specific N-glycosylation characterization requires intact N-glycopeptide analysis based on suitable tandem mass spectrometry (MS/MS) method. Electron-transfer/higher-energy collisional dissociation (EThcD), stepped collision energy/higher-energy collisional dissociation (sceHCD), and higher-ene...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030288 | Pride
Glycoproteomics Mass spectrometry Ethcd-scehcd Fragmentation mode N-glycosylation Clinical sample 
UnknownThe prevalence and risk factors of posttraumatic cerebral infarction in patients with traumatic brain injury: a systematic review and meta-analysis.
Not available
S-EPMC9275913 | biostudies-literature
UnknownNumerical Analysis of Three-dimensional Nanodisk Array-based Surface Plasmon Resonance Biosensors for SARS-CoV-2 Detection.
Not available
S-EPMC9947906 | biostudies-literature
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