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TranscriptomicsTranscriptional interaction network analyses in dorsal nucleus of vagus nerve, locus coeruleus and substantia nigra in Parkinson's disease
We analyzed the transcriptomic profile of post-mortem explants from dorsal nucleus of vagus nerve, locus coeruleus and substantia nigra obtained from controls and Braak 4 (BK4) and 5 (BK5) stages of Parkinson’s disease (PD) patients in order to investigate how gene-gene interaction patterns vary alo...
ORGANISM(S): Homo sapiens 
2015-01-11 | E-GEOD-43490 | biostudies-arrayexpress
ProteomicsHuman substantia nigra proteome dataset
Quantitative proteomic analysis of human post-mortem substantia nigra from patients with Parkinson’s disease (n=3) versus controls (n=3) based on sixplex TMT (TMT6) isobaric labeling which allowed protein simultaneous identification and quantification. Samples were digested and pooled after TMT6 lab...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-10 | MSV000083948 | MassIVE
ProteomicsDon’t die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?
A hallmark of Parkinson’s disease is the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta. Interestingly, not all of these neurons are equally affected. Studies revealed that neurons located more ventrally within the substantia nigra pars compacta have a higher pre...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD037696 | Pride
Neurons Mass spectrometry Proteomic Selective neuronal vulnerability Substantia nigra 
TranscriptomicsAge-mediated transcriptomic changes in adult mouse substantia nigra
Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease. Until now, molecular mechanisms behind SNpc aging have not been fully investigated using high throughput techniques. Here, aging-associated early changes in transcriptome of ...
ORGANISM(S): Mus musculus 
2013-05-29 | E-GEOD-45043 | biostudies-arrayexpress
GenomicsControl human putamen and Substantia Nigra
The study is affiliated to the UKBEC sample of healthy human putamen and substantia nigra phenotype. The gender is from both male and female samples of the the phenotype.
EGAS00001003065 | EGA
ProteomicsSpiked human substantia nigra proteome data set for use as a spectral library for protein modelling and protein mapping
This article describes a mass spectrometry data set generated from human substantia nigra tissue that was spiked with iRT peptides. The data set can be used as a spectral library for analysis of the human brain, especially human substantia nigra, for example, in the context of Parkinson’s disease. O...
ORGANISM(S): Homo sapiens (Human) 
2019-08-15 | PXD011076 | Pride
Substantia nigra Protein modelling Spectral library Dda 
TranscriptomicsTranscription profiling of human Parkinsons medial and substania nigra
Affymetrix HG_U133 array sets (A and B chips) were used to determine the whole genome transcription profile of clinically documented and neuropathologically confirmed cases of sporadic Parkinson's disease as well as controls. Experiment Overall Design: Post mortem brain tissue samples from Parkinson...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8397 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling by high-throughput sequencing in the substantia nigra and striatum of Multiple System Atrophy (MSA) transgenic mice and wild type controls
Multiple system atrophy (MSA) is a fatal rapidly progressive Ia-synucleinopathy, characterized by prominent Ia-synuclein accumulation in oligodendrocytes. In this study we investigated miRNA expression in the substantia nigra and striatum of MSA transgenic mice (Tg(Plp1-SNCA)1Haa) and wild type cont...
ORGANISM(S): Mus musculus 
2016-03-15 | E-MTAB-3993 | biostudies-arrayexpress
TranscriptomicsmiRNA microarray analysis of the substantia nigra and stratum in a mouse model of multiple system atrophy
Multiple system atrophy (MSA) is a fatal rapidly progressive α-synucleinopathy, characterized by prominent α-synuclein accumulation in oligodendrocytes. In this study we used Exiqon microarrays to investigate micro RNA expression in substantia nigra and striatum of MSA transgenic mice (Tg(Plp1-SNC...
ORGANISM(S): Mus musculus 
2016-03-15 | E-MTAB-3986 | biostudies-arrayexpress
TranscriptomicsWhole Transcriptome Analysis of Substantia Nigra in Mice with MPTP-Induced Parkinsonism Bearing Defective Glucocerebrosidase Activity
We characterized the transcriptomic profiles of cells from the substantia nigra (SN) of mice with co-injection with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and selective inhibitor of GCase activity (conduritol-β-epoxide, (CBE)) to mimic PD bearing GCase dysfunction (MPTP+CBE), mice treat...
ORGANISM(S): Mus musculus 
2023-08-31 | E-MTAB-13244 | biostudies-arrayexpress
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