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UnknownDiscovery and substrate specificity engineering of nucleotide halogenases.
Not available
S-EPMC11186838 | biostudies-literature
ProteomicsKinase-catalyzed Biotinylation for Discovery and Validation of Substrates to Multi-specificity Kinases NME1 and NME2
Protein phosphorylation by kinases regulates mammalian cell functions, such as growth, division, and signal transduction. Among human kinases, NME1 and NME2 are associated with metastatic tumor suppression, but remain understudied due to the lack of tools to monitor their cellular substrates. In par...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051411 | Pride
Proteomics Histidine kinase Phosphorylation Nme Substrate specificity Atp-biotin Protein kinase 
ProteomicsDevelopment of Substrate-Directed Activity-Based Probes via Disulfide-Trapping for Site-Specific Interrogation of Nucleosomal Deubiquitination
Activity-based ubiquitin probes (Ub-ABPs) have been instrumental in interrogating deubiquitinases (DUBs), yet conventional Ub-ABPs lack the substrate-specific and site-specific contextual cues required to investigate nucleosomal DUBs, whose activity is tightly regulated by the chromatin environments...
ORGANISM(S): Homo Sapiens 
2025-12-30 | PXD072417 |
UnknownHDAC6 Substrate Discovery Using Proteomics-Based Substrate Trapping: HDAC6 Deacetylates PRMT5 to Influence Methyltransferase Activity.
Not available
S-EPMC8939004 | biostudies-literature
UnknownBacterial cytochrome P450s: a bioinformatics odyssey of substrate discovery.
Not available
S-EPMC10879549 | biostudies-literature
ModelsGonzalez2021 - QSAR Prediction Model for CYP2D6 Inhibitor and Substrate
Analysis of metabolic stability, determining the inhibition of CYP2D6 activity and whether the compounds are a substrate for the CYP2D6 enzyme. The data used to build these models has been publicly available at PubChem (AID1645840) by ADME@NCATS. Model Type: Predictive machine learning model. Model...
2024-05-10 | MODEL2404160003 | BioModels
Machine Learning Model Ersilia 
ModelsGonzalez2021 - QSAR Prediction Model for CYP3A4 Inhibitor and Substrate
Analysis of metabolic stability, determining the inhibition of CYP3A4 activity and whether the compounds are a substrate for the CYP3A4 enzyme. The data used to build these models has been publicly available at PubChem (AID1645841) by ADME@NCATS. Model Type: Predictive machine learning model. Model...
2024-05-10 | MODEL2404160001 | BioModels
Machine Learning Model Ersilia 
ModelsGonzalez2021 - QSAR Prediction Model for CYP2C9 Inhibitor and Substrate
Analysis of metabolic stability, determining the inhibition of CYP2C9 activity and whether the compounds are a substrate for the CYP2C9 enzyme. The data used to build these models has been publicly available at PubChem (AID1645842) by ADME@NCATS. Model Type: Predictive machine learning model. Model...
2024-04-16 | MODEL2404160002 | BioModels
Machine Learning Model Ersilia 
GenomicsIn silico APC/C substrate discovery reveals cell-cycle-dependent degradation of UHRF1 and other chromatin regulators
In silico APC/C substrate discovery reveals cell-cycle-dependent degradation of UHRF1 and other chromatin regulators
PRJNA573856 | ENA
UnknownA Silent Biosynthetic Gene Cluster from a Methanotrophic Bacterium Potentiates Discovery of a Substrate Promiscuous Proteusin Cyclodehydratase.
Not available
S-EPMC9746716 | biostudies-literature
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