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MetabolomicsInhibition of anaerobic digestion by various ammonia sources resulted in subtle differences in metabolite dynamics

The impact of ammonia on anaerobic digestion performance and microbial dynamics has been extensively studied, but the concurrent effect of anions brought by ammonium salt should not be neglected. This paper studied this effect using metabolomics and a time-course statistical framework. Metabolomi...

2024-03-01 | MTBLS7859 | MetaboLights
Proteomicsβ-Carotene alleviates substrate inhibition caused by asymmetric cooperativity
Enzymes play a crucial role in biological systems and biotechnological processes as vital and sustainable catalysts that facilitate and regulate biochemical reactions. Inhibition of product formation of an enzyme by its own substrate was originally dismissed as an artifact of biochemical analysis, b...
ORGANISM(S): Nicotiana benthamiana 
2025-03-06 | PXD056344 | Pride
Hdxms X-ray crystallography Substrate inhibition Ugt Nicotiana benthamiana 
GenomicsStructural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
PRJNA624321 | ENA
ModelsGonzalez2021 - QSAR Prediction Model for CYP2D6 Inhibitor and Substrate
Analysis of metabolic stability, determining the inhibition of CYP2D6 activity and whether the compounds are a substrate for the CYP2D6 enzyme. The data used to build these models has been publicly available at PubChem (AID1645840) by ADME@NCATS. Model Type: Predictive machine learning model. Model...
2024-05-10 | MODEL2404160003 | BioModels
Machine Learning Model Ersilia 
ModelsGonzalez2021 - QSAR Prediction Model for CYP3A4 Inhibitor and Substrate
Analysis of metabolic stability, determining the inhibition of CYP3A4 activity and whether the compounds are a substrate for the CYP3A4 enzyme. The data used to build these models has been publicly available at PubChem (AID1645841) by ADME@NCATS. Model Type: Predictive machine learning model. Model...
2024-05-10 | MODEL2404160001 | BioModels
Machine Learning Model Ersilia 
ModelsGonzalez2021 - QSAR Prediction Model for CYP2C9 Inhibitor and Substrate
Analysis of metabolic stability, determining the inhibition of CYP2C9 activity and whether the compounds are a substrate for the CYP2C9 enzyme. The data used to build these models has been publicly available at PubChem (AID1645842) by ADME@NCATS. Model Type: Predictive machine learning model. Model...
2024-04-16 | MODEL2404160002 | BioModels
Machine Learning Model Ersilia 
ModelsGonzalez2021 - QSAR Prediction Model for CYP450 enzymes Inhibitor and Substrate
Analysis of metabolic stability, determining the inhibition of CYP450 activity and whether the compounds are a substrate for the CYP450 enzymes. The data used to build these models is publicly available at PubChem (AID1645840, AID1645841, AID1645842). The tested cyps include CYP2C9, CYP2D6 and CYP3A...
2024-05-10 | MODEL2404160004 | BioModels
Machine Learning Model Ersilia 
UnknownHuman soluble CD39 displays substrate inhibition in a substrate-specific manner.
Not available
S-EPMC10238538 | biostudies-literature
UnknownStructural insights into substrate traffic and inhibition in acetylcholinesterase.
Not available
S-EPMC1500847 | biostudies-literature
Unknownβ-Carotene alleviates substrate inhibition caused by asymmetric cooperativity.
Not available
S-EPMC11954892 | biostudies-literature
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