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MetabolomicsCoupled nitrogen fixation and substrate stabilization drive ecological strategy shifts during microbial succession

Background:

Primary succession is predicted to proceed through shifts from stress-tolerant to competitive to cooperative ecological strategies as resource availability increases, yet molecular evidence for these transitions in microbial systems remains limited. Here, we used an integrated m...

2026-03-12 | MTBLS14041 | MetaboLights
ProteomicsIdentification of AMPK phosphorylation sites reveals a network of proteins involved in cell invasion and facilitates large-scale substrate prediction
AMP-activated protein kinase (AMPK) is a central energy gauge that regulates metabolism and has been increasingly involved in non-metabolic processes and diseases. However, AMPK’s direct substrates in non-metabolic contexts are largely unknown. To better understand the AMPK network, we use a chemica...
ORGANISM(S): Homo sapiens (Human) 
2015-10-09 | PXD003019 | Pride
Substrate identification Ampk Phosphorylation Substrate prediction 
MetabolomicsDynamic utilization of low-molecular-weight organic substrates across a microbial growth rate gradient

AIM: Low-molecular-weight organic substances (LMWOSs) are at the nexus between micro-organisms, plant roots, detritus and the soil mineral matrix. The nominal oxidation state of carbon (NOSC) has been suggested as a potential parameter for modelling microbial uptake rates of LMWO...

2023-08-14 | MTBLS3558 | MetaboLights
ModelsGonzalez2021 - QSAR Prediction Model for CYP2D6 Inhibitor and Substrate
Analysis of metabolic stability, determining the inhibition of CYP2D6 activity and whether the compounds are a substrate for the CYP2D6 enzyme. The data used to build these models has been publicly available at PubChem (AID1645840) by ADME@NCATS. Model Type: Predictive machine learning model. Model...
2024-05-10 | MODEL2404160003 | BioModels
Machine Learning Model Ersilia 
ModelsGonzalez2021 - QSAR Prediction Model for CYP3A4 Inhibitor and Substrate
Analysis of metabolic stability, determining the inhibition of CYP3A4 activity and whether the compounds are a substrate for the CYP3A4 enzyme. The data used to build these models has been publicly available at PubChem (AID1645841) by ADME@NCATS. Model Type: Predictive machine learning model. Model...
2024-05-10 | MODEL2404160001 | BioModels
Machine Learning Model Ersilia 
ModelsGonzalez2021 - QSAR Prediction Model for CYP2C9 Inhibitor and Substrate
Analysis of metabolic stability, determining the inhibition of CYP2C9 activity and whether the compounds are a substrate for the CYP2C9 enzyme. The data used to build these models has been publicly available at PubChem (AID1645842) by ADME@NCATS. Model Type: Predictive machine learning model. Model...
2024-04-16 | MODEL2404160002 | BioModels
Machine Learning Model Ersilia 
ModelsGonzalez2021 - QSAR Prediction Model for CYP450 enzymes Inhibitor and Substrate
Analysis of metabolic stability, determining the inhibition of CYP450 activity and whether the compounds are a substrate for the CYP450 enzymes. The data used to build these models is publicly available at PubChem (AID1645840, AID1645841, AID1645842). The tested cyps include CYP2C9, CYP2D6 and CYP3A...
2024-05-10 | MODEL2404160004 | BioModels
Machine Learning Model Ersilia 
UnknownKinase-substrate prediction using an autoregressive model.
Not available
S-EPMC11968300 | biostudies-literature
TranscriptomicsKinase activity profiling of human locally advanced rectal cancer samples
Locally advanced rectal cancer characterized by multiplex kinase activity profiling
ORGANISM(S): Homo sapiens 
2010-08-05 | E-TABM-913 | biostudies-arrayexpress
ProteomicsProteomic QSAR analysis of calpain substrate specificity
Calpains are intracellular Ca2+-regulated cysteine proteases that are essential for various cellular functions. Mammalian conventional calpains (calpain-1 and calpain-2) modulate the structure and function of their substrates by limited proteolysis; however, their substrate specificity remains uncle...
ORGANISM(S): Bos taurus (Bovine) Oryctolagus cuniculus algirus Mus musculus (Mouse) Homo sapiens (Human) Gallus gallus (Chicken) Ovis aries Sus scrofa domesticus (domestic pig) Rattus norvegicus (Rat) 
2016-07-19 | PXD002532 | Pride
Calpain Pls Qsar Substrate specificity 
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