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MetabolomicsMetabolic Substrate Availability Regulates Nephron Lineage Expansion in Human Kidney Organoids
Human induced pluripotent stem cell-derived kidney organoids are widely used to model nephrogenesis, but variability in basal media composition remains an underappreciated source of developmental heterogeneity. Because nephrogenesis involves rapid proliferation and differentiation, we hypothesized t...
2026-10-18 | MTBLS16048 | MetaboLights
MetabolomicsCoupled nitrogen fixation and substrate stabilization drive ecological strategy shifts during microbial succession

Background:

Primary succession is predicted to proceed through shifts from stress-tolerant to competitive to cooperative ecological strategies as resource availability increases, yet molecular evidence for these transitions in microbial systems remains limited. Here, we used an integrated m...

2026-03-12 | MTBLS14041 | MetaboLights
MetabolomicsMetabolite profiling of Arabidopsis mutants of enzymes of lower glycolysis
We have previously shown that in Arabidopsis the three enzymes of lower glycolysis phosphoglycerate mutase (PGAM), enolase and pyruvate kinase form a complex which play an important role in co-sub-cellar localization the mitochondria to the chloroplast. Given that their metabolites of these mutants,...
2022-10-10 | MTBLS4066 | MetaboLights
MetabolomicsExometabolomic profiling of bacterial strains cultivated using Arabidopsis root extract as the sole carbon source
The ability of microorganisms to use root-derived metabolites as growth substrates is a key trait for success in the rhizospheric niche. However, few studies describe which specific metabolites are consumed, or to what degree microbial strains differ in their substrate consumption patterns. Here we ...
2018-10-16 | MTBLS555 | MetaboLights
MetabolomicsGlyceraldehyde-3-phosphate dehydrogenase homologs as bifunctional gatekeepers of metabolic segregation in Pseudomonas putida

Metabolically versatile Pseudomonas species can assimilate various glycolytic and gluconeogenic substrates. Simultaneous assimilation is known to involve segregating carbons from each substrate type into different metabolic pathways, but the mechanisms that govern this segregation remain unresolv...

2025-11-03 | MTBLS12468 | MetaboLights
MetabolomicsMetabolomic Profiling Following Sin A Treatment

Schisantherin A, a natural product, safely alleviates obesity and associated metabolic disorders by orchestrating crosstalk among immune, neuronal, adipose cells, metabolic organs, and gut bacteria via increased circulating conjugated bile acids.

2025-11-21 | MTBLS13266 | MetaboLights
ProteomicsSubstrate specificity of Pseudomonas aeruginosa protease LasB using multiplex substrate profiling by mass spectrometry
Substrate specificity of Pseudomonas aeruginosa protease LasB using multiplex substrate profiling by mass spectrometry
ORGANISM(S): Pseudomonas Aeruginosa (ncbitaxon:287) 
2017-10-18 | MSV000081623 | MassIVE
ProteomicsSubstrate specificity of Pseudomonas aeruginosa protease LasB using multiplex substrate profiling by mass spectrometry
Substrate specificity of Pseudomonas aeruginosa protease LasB using multiplex substrate profiling by mass spectrometry
ORGANISM(S): Synthetic 228-peptide Library 
2017-08-18 | MSV000081465 | MassIVE
ProteomicsSubstrate profiling of the metalloproteinase ovastacin – Implications for its physiological function in mammalian fertilization
The metalloproteinase ovastacin is released by the mammalian oocyte upon fertilization and cleaves zona pellucida protein 2, a component of the surrounding extracellular matrix, at a distinct cleavage site. This limited proteolysis hardens the zona pellucida, abolishes sperm binding and thereby regu...
ORGANISM(S): Mus Musculus (mouse) 
2023-09-15 | PXD038561 | JPOST Repository
TranscriptomicsKinase activity profiling of human locally advanced rectal cancer samples
Locally advanced rectal cancer characterized by multiplex kinase activity profiling
ORGANISM(S): Homo sapiens 
2010-08-05 | E-TABM-913 | biostudies-arrayexpress
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