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MetabolomicsMulti-omics analysis reveals the potential for feed utilization of Cordyceps militaris mushroom substrate in laying hens

Background The intestinal microbiota, metabolites, and quorum-sensing (QS) functions of laying hens under different proportions of fermented Cordyceps militaris mushroom substrate (CMMS) replacement diets are critical for their production performance and health. However, the changes in the intest...

2025-09-09 | MTBLS12825 | MetaboLights
TranscriptomicsRNA-seq reveals that Air1 and Air2 control TRAMP substrate specificity for nuclear RNA surveillance
The Saccharomyces cerevisiae TRAMP4 and TRAMP5 complexes, which consist of the poly(A) polymerase Trf4 or Trf5, respectively, the zinc knuckle proteins Air1 or Air2, and the RNA helicase Mtr4, play a critical role in nuclear RNA surveillance. Although it is known to enhance the nuclease activity of ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-11-14 | E-GEOD-42231 | biostudies-arrayexpress
TranscriptomicsPhenotype modulation of VSMCs on patterned substrate
Loss of contractility and acquisition of an epithelial phenotype of vascular smooth muscle cells (VSMCs) are key events in proliferative vascular pathologies such as atherosclerosis and post-angioplastic restenosis. There is no proper cell culture system allowing VSMC differentiation so that it is d...
ORGANISM(S): Rattus norvegicus 
2013-11-14 | E-MTAB-1888 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of preadipocytes of wild type and IRS-1,IRS-2, IRS-3, IRS-4 knock out mice to reveal role of insulin receptor substrates and necdin
Insulin and IGF-1 promote adipocyte differentiation via complex and overlapping signalling networks. Here we used microarray analysis of brown preadipocytes derived from wild-type and insulin receptor substrate (IRS) knockout (KO) animals, which exhibited progressively impaired differentiation, to ...
ORGANISM(S): Mus musculus 
2007-08-04 | E-GEOD-2556 | biostudies-arrayexpress
ProteomicsAndrogen receptor RIME using LNCaP cells
Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) was conducted to examine interactome of androgen receptor (AR) in LNCaP cells.
ORGANISM(S): Homo Sapiens (human) 
2021-09-10 | PXD024030 | JPOST Repository
ProteomicsMechanism of cooperative strigolactone perception by the MAX2 ubiquitin ligase–receptor–substrate complex
Strigolactones are plant hormones that regulate development and mediate interactions with soil organisms, including the germination of parasitic plants such as Striga hermonthica. Strigolactone perception by receptors initiates the degradation of transcriptional repressors via E3 ubiquitin ligases, ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Striga hermonthica 
2025-09-19 | PXD068313 | Pride
E3 ligase Cryo-em Plant hormone Hdx-ms 
GenomicsInsulin Receptor Substrate 2 regulates placental syncytiotrophoblast differentiation at the maternal-fetal interface
Insulin Receptor Substrate 2 regulates placental syncytiotrophoblast differentiation at the maternal-fetal interface
PRJNA1365247 | ENA
ProteomicsMotif-based substrate mapping of the receptor-like cytoplasmic kinase BIK1 reveals novel components and regulatory nodes of plant immunity
Plant cell surface pattern recognition receptors (PRRs) perceive non- or altered-self elicitors to induce immune responses. PRRs relay information across the plasma membrane and trigger downstream signaling via receptor-like cytoplasmic kinases (RLCKs) such as BOTRYTIS-INDUCED KINASE 1 (BIK1). BIK1 ...
ORGANISM(S): Arabidopsis Thaliana 
PXD066643 | panorama
ProteomicsStructural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange
Modular SCF (SKP1-CUL1-Fbox) ubiquitin E3 ligases orchestrate multiple cellular pathways in eukaryotes. Their variable SKP1-Fbox substrate receptor (SR) modules enable regulated substrate recruitment and subsequent proteasomal degradation. CAND proteins are essential for the efficient and timely exc...
ORGANISM(S): Homo sapiens (Human) 
2023-09-18 | PXD042178 | Pride
Human Cand1 Cryo-em Hdx-ms 
GenomicsDeletion of KLHDC3, an E3 ubiquitin ligase complex substrate receptor, leads to obesity in mice
Deletion of KLHDC3, an E3 ubiquitin ligase complex substrate receptor, leads to obesity in mice
PRJNA1134239 | ENA
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