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MetabolomicsSex and subtype differences shape the blood metabolome profiles in Parkinson's disease.

Rationale: Sex and type of Parkinson's disease (PD) significantly influence onset age, clinical manifestations, treatment response, disease progression and life expectancy. However, the selective influence of idiopathic and familial forms of PD in disrupting blood metabolome profiles across gende...

2025-09-03 | MTBLS11187 | MetaboLights
MetabolomicsMultiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level (Metabolite profiling)

Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. The application of omics technologies - mainly studying nucleic acids - has significantly improved MB classification and stratification, but treatment options are still unsatisfactor...

2024-05-30 | MTBLS9830 | MetaboLights
MetabolomicsMultiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level (Amino acid profiling)

Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. The application of omics technologies - mainly studying nucleic acids - has significantly improved MB classification and stratification, but treatment options are still unsatisfactor...

2024-05-30 | MTBLS9836 | MetaboLights
TranscriptomicsImpact of Gene Expression Profiling Based Risk Stratification in Patients with Myeloma Receiving Initial Therapy with Lenalidomide and Dexamethasone
Detection of specific chromosomal abnormalities by FISH and metaphase cytogenetics allows risk stratification in multiple myeloma (MM); however, gene expression profiling (GEP) based signatures may enable more specific risk categorization. We examined the utility of two GEP-based risk stratification...
ORGANISM(S): Homo sapiens 
2011-08-25 | E-GEOD-31504 | biostudies-arrayexpress
TranscriptomicsClassification of Myeloma Using Global MicroRNA Profiling
Myeloma is a heterogeneous disease. In this work we used global microRNA profiling to classify clinical samples from UK MRC Myeloma IX, and developed a microRNA-based M-bM-^@M-^\outcome classifierM-bM-^@M-^] for risk stratification. Global microRNA expression profiling was carried out in 163 newly d...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-41276 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bone marrow samples of 31 children with acute lymphoblastic leukemia to identify changes in gene expression that are associated with the current risk assignment, irrespective of the genetic subtype
We analyzed bone marrow samples of 31 children with acute lymphoblastic leukemia to identify changes in gene expression that are associated with the current risk assignment, irrespective of the genetic subtype
ORGANISM(S): Homo sapiens 
2004-06-28 | E-MEXP-120 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of FFPE Pre-treatment Endoscopic Biopsies from Oesophageal Adenocarcinoma Patients Treated with Neo-adjuvant Chemotherapy and Surgical Resection
Gene expression profiling of 273 pre-treatment endoscopic FFPE oesophageal and oesophago-gastric junctional adenocarcinomas for validation of a DNA Damage Response Deficiency Assay. All patients were treated with neo-adjuvant chemotherapy followed by surgical resection and were collected at four UK ...
ORGANISM(S): Homo sapiens 
2019-01-31 | E-MTAB-6969 | biostudies-arrayexpress
UnknownA Pan-Subtype Fatty Acid Metabolic Signature Reveals Universal Prognostic Stratification in Breast Cancer.
Not available
S-EPMC12789645 | biostudies-literature
TranscriptomicsCentrosome associated genes pattern for risk sub-stratification in multiple myeloma
This experiment follows, extends and validates our previous findings published in Leukemia & Lymphoma as original article entitled \Molecular heterogeneity and centrosome-associated genes in multiple myeloma\. [Kryukov F, Nemec P, et al, Leuk Lymphoma. 2013 Sep;54(9):1982-8. Doi: 10.3109/10428194.2...
ORGANISM(S): Homo sapiens 
2016-05-01 | E-MTAB-4032 | biostudies-arrayexpress
TranscriptomicsStratification of Leiomyosarcoma molecular subtypes by 3' end RNA-sequencing: Toward precision medicine
Leiomyosarcoma (LMS) is a malignant neoplasm with smooth muscle differentiation. Little is known about its molecular heterogeneity and no targeted therapy currently exists for LMS. We demonstrate the existence of 3 molecular subtypes in a cohort of 99 cases and an independent cohort of 82 LMS. Tw...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-45510 | biostudies-arrayexpress
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