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MetabolomicsLow chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk
Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, co...
2021-10-06 | MTBLS2148 | MetaboLights
MetabolomicsOn-line untargeted metabolomics monitoring of an Escherichia coli succinate fermentation process
The real-time monitoring of metabolites (RTMet) is instrumental for the industrial production of biobased fermentation products. This study shows the first application of untargeted on-line metabolomics for the monitoring of undiluted fermentation broth samples taken automatically from a 5 L bioreac...
2023-04-26 | MTBLS5197 | MetaboLights
MetabolomicsIntestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets
Diarrheal disease is a common health problem with complex causality. Although diarrhea is accompanied by disturbances in microbial diversity, how gut microbes are involved in the occurrence of diarrhea remains largely unknown. Here, using a pig model of post-weaning stress-induced diarrhea, we aim t...
2023-01-09 | MTBLS4040 | MetaboLights
MetabolomicsSuccinate drives macrophage inflammation by promoting GPR91 mitochondrial signaling in rheumatoid arthritis

Succinate is implicated in rheumatoid arthritis (RA) and other inflammatory diseases via its receptor, G protein-coupled receptor 91 (GPR91). Despite its therapeutic potential, conflicting reports on its inflammatory roles have hindered GPR91-targeted treatm...

2026-02-05 | MTBLS13828 | MetaboLights
MetabolomicsSuccinate accumulation drives ischaemia-reperfusion injury during organ transplantation
During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient. Despite its widespread use, our understanding of the m...
2019-09-20 | MTBLS1085 | MetaboLights
MetabolomicsLuminal succinate in UC-HMA (human microbiota-associated) mice.
Not available
ORGANISM(S): Mus musculus 
ST001287 | MetabolomicsWorkbench
MetabolomicsBacteroides acidifaciens Derived Succinate Mediates Gynostemma pentaphyllum Polysaccharides' Effects on Muscle Fiber Switching and Exercise Endurance

Enhancing exercise endurance holds significant practical implications for boosting the physical fitness of the general population to address daily challenges and improving the physical capabilities and quality of life of patients with relevant diseases. Polysaccharides from Gynostemma pentaphyllu...

2025-10-28 | MTBLS13229 | MetaboLights
TranscriptomicsEthylamine versus succinate cells of Methylobacterium extorquens
In order to provide global information on gene expression during growth on C2 compounds, microarray analysis of M. extorquens AM1 cells was carried out, comparing ethylamine-grown cells to succinate-grown cells. This comparison has confirmed previous observations on the inducible nature of some of t...
ORGANISM(S): Methylobacterium extorquens 
2010-05-14 | E-GEOD-20365 | biostudies-arrayexpress
MetabolomicsMetabolome Profiling of Synechococcus elongatus PCC 11801 strains engineered for Succinate Production
Not available
ORGANISM(S): Synechococcus elongatus PCC 11801 
ST001298 | MetabolomicsWorkbench
MetabolomicsDistinct succinate modifying products are clinically diagnostic and prognostic biomarkers for fumarate hydratase deficient renal cell carcinoma

Germline or somatic loss-of-function of fumarate hydratase (FH) predisposes patients to an aggressive form of renal cell carcinoma (RCC). Since other than tumor resection, there is no effective therapy for FH-deficient RCC, a competent method for early diagnosis and for early detection of recurre...

2022-08-12 | MTBLS3628 | MetaboLights
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