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TranscriptomicsRNAi profiling of Drosophila Schneider S2 cells treated with dsRNA vs. GFP
Cis-natural antisense transcripts (cis-NATs) have been speculated to be substrates for endogenous RNA interference (RNAi), but little experimental evidence for such a pathway in animals has been reported. Analysis of massive Drosophila melanogaster small RNA data sets now reveals that endogenous sma...
ORGANISM(S): Drosophila melanogaster 
2008-06-20 | E-GEOD-11370 | biostudies-arrayexpress
TranscriptomicsPustular psoriasis: molecular pathways and effects of spesolimab in generalized pustular psoriasis
pre- and post spesolimab treatment gene expression analysis of blood as well as skin biopsy samples.
ORGANISM(S): Homo sapiens 
2023-06-04 | E-MTAB-11144 | biostudies-arrayexpress
TranscriptomicsExpression profile of peripheral blood of healthy individuals phenotyped based on â??Prakritiâ?? concept of Ayurveda
Immense phenotypic variability exists among healthy individuals which is a consequence of both genetic and environmental effects. Genome wide expression variability is a powerful tool for capturing these expression variations and hence can give insights into genotype phenotype correlations. In the a...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-7883 | biostudies-arrayexpress
GenomicsIdentification of enhancers in EMT and breast cancer stem cell formation
Epithelial-mesenchymal transition (EMT), the process whereby cells gain migratory and invasive properties characteristic of mesenchymal cells, plays a central role in embryogenesis and wound healing in a wide range of tissues. However, EMT has also been linked to the formation of cancer stem cells (...
ORGANISM(S): Homo sapiens 
2016-03-10 | E-GEOD-76732 | biostudies-arrayexpress
TranscriptomicsExercise dependent gene regulation in cartilage
Objective. Exercise is crucial for maintaining cartilage integrity and providing prophylaxis against the onset of osteoarthritis (OA). Here we systematically examined the exercise driven transcriptional activation/repression of genes from healthy articular cartilage to dissect the metabolic pathways...
ORGANISM(S): Rattus norvegicus 
2015-11-10 | E-GEOD-74898 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from B6 and 129 mice fed on low and high fat diets
Both environmental and genetic factors play important roles in the development of the metabolic syndrome. To elucidate how these factors interact under normal conditions, C57Bl/6 (B6) and 129S6/SvEvTac (129) mice were placed on a low-fat or high-fat diet. Liver samples were extracted and hybridized...
ORGANISM(S): Mus musculus 
2007-04-06 | E-CBIL-24 | biostudies-arrayexpress
GenomicsIdentification of chromatin accessibility domains in EMT and breast cancer stem cell formation.
Epithelial-mesenchymal transition (EMT), the process whereby cells gain migratory and invasive properties characteristic of mesenchymal cells, plays a central role in embryogenesis and wound healing in a wide range of tissues. However, EMT has also been linked to the formation of cancer stem cells (...
ORGANISM(S): Homo sapiens 
2016-03-10 | E-GEOD-71023 | biostudies-arrayexpress
TranscriptomicsRegulation of Mouse Lens Development and Gene Expression by Krüppel-Like Factor 4
Conditional disruption of Klf4 in the ectoderm-derived tissues of the eye results in defective cornea, conjunctiva and the lens. Expression of Klf4 is first detected in the embryonic day-12 (E12) mouse lens, peaks at E16, and declines thereafter. Lenses from Mice which were conditional null for Klf4...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-47694 | biostudies-arrayexpress
TranscriptomicsDynamic changes in the functions of Klf5 in maturing mouse corneas revealed by the changes in its target genes at postnatal days 11 and 56
Purpose: Klf5 plays a critical role in the mouse ocular surface (Kenchegowda et al., 2011. Dev Biol. 356:5-18). Here, we compare wild-type (WT) and Klf5-conditional null (Klf5CN) corneal gene expression at postnatal day-11 (PN11) and PN56 to identify the Klf5-target genes. Methods: Gene expression ...
ORGANISM(S): Mus musculus 
2012-12-25 | E-GEOD-36229 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human ex vivo ovarian cancer models - part III
Ascites or solid tumour samples from patients with ovarian cancer were collected and grown in culture as ex vivo models of purified tumour cells. RNA-seq was performed on these models to establish gene expression profiles, which allow identification of genes that are differentially expressed between...
ORGANISM(S): Homo sapiens 
2021-10-10 | E-MTAB-11000 | biostudies-arrayexpress
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