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TranscriptomicsHoxB4 in hematopoietic stem cells
Ectopic expression of homeodomain transcription factor HoxB4 in mouse ES cells enhances in vitro development of hematopoietic stem cells (HSCs). Mouse ES cells were differentiated for 6 days in EBs, then c-Kit+CD41+ hematopoietic precursor cells were isolated, plated onto OP9 cells, and transduced w...
ORGANISM(S): Mus musculus 
2011-05-23 | E-GEOD-26653 | biostudies-arrayexpress
ProteomicsPhosphorylation of two Thr residues in the C-terminal auto-inhibitory domain of plasma membrane H+-ATPase is crucial for light-induced stomatal opening-2
Plasma membrane H+-ATPase provides the driving force for light-induced stomatal opening. However, the mechanisms underlying the regulation of its activity remain unclear. Here, we showed that the phosphorylation of two Thr residues in the C-terminal autoinhibitory domain is crucial for H+-ATPase...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2023-12-25 | PXD044476 | JPOST Repository
ProteomicsPhosphorylation of two Thr residues in the C-terminal auto-inhibitory domain of plasma membrane H+-ATPase is crucial for light-induced stomatal opening
Plasma membrane H+-ATPase provides the driving force for light-induced stomatal opening. However, the mechanisms underlying the regulation of its activity remain unclear. Here, we showed that the phosphorylation of two Thr residues in the C-terminal autoinhibitory domain is crucial for H+-ATPase act...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2023-12-25 | PXD039740 | JPOST Repository
ProteomicsPhosphorylation of WDR48 by phototropins drives starch degradation to promote stomatal opening
Plant stomata open in response to blue light under a background of red light. Red light induces starch accumulation through guard cell photosynthesis, whereas blue light causes rapid starch degradation via the activation of plasma membrane H+-ATPase through phosphorylation of BLUS1 by phototropins, ...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2026-02-18 | PXD073138 | JPOST Repository
TranscriptomicsSpatial interplay between Polycomb and Trithorax complexes controls transcriptional activity in T lymphocytes
Trithorax group (TrxG) and Polycomb group (PcG) proteins are two mutually antagonistic chromatin modifying complexes, however, how they together mediate transcriptional counterregulation remains unknown. Genome-wide analysis revealed that binding of Ezh2 and Menin, central members of the PcG and Tr...
ORGANISM(S): Mus musculus 
2015-09-08 | E-GEOD-72757 | biostudies-arrayexpress
ProteomicsSerum proteome profiling of patients with non-small cell lung cancer treated with immune checkpoint blockade monotherapy
Shotgun proteomic profiling of serum from patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint blockade (ICB) monotherapy. Top-14 abundant proteins were depleted (Pierce High-Select, Thermo Fisher Scientific), and tryptic digests were spiked with the Pierce Peptide Retenti...
ORGANISM(S): Homo Sapiens (human) 
2026-06-10 | PXD078247 | JPOST Repository
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