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GenomicsGenome-wide Analysis Reveals Conserved and Divergent Features of Notch1/RBPJ Binding in Human and Murine T Lymphoblastic Leukemia Cells
Notch1 regulates gene expression by associating with the DNA-binding factor RBPJ and is oncogenic in murine and human T cell progenitors. Using ChIP-Seq, we find that in human and murine T-LL genomes Notch1 binds preferentially to promoters, to RBPJ binding sites, and near imputed ZNF143, Ets and Ru...
ORGANISM(S): Mus musculus 
2011-07-06 | E-GEOD-29600 | biostudies-arrayexpress
GenomicsEpstein-Barr Virus Exploits Intrinsic B-Lymphocyte Transcription Programs to Achieve Immortal Cell Growth
Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) gene regulation through the cell RBPJ transcription factor (TF) is essential for conversion of resting B-lymphocytes (RBLs) into Lymphoblastoid Cell Lines (LCLs). ChIP-seq investigation of EBNA2 and RBPJ sites in LCL DNA found EBNA2 at 5151 and RBPJ at 10...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-29498 | biostudies-arrayexpress
UnknownAtomically Thin, Optically Isotropic Films with 3D Nanotopography.
Not available
S-EPMC8431725 | biostudies-literature
UnknownLabel-free nanoscale optical metrology on myelinated axons in vivo.
Not available
S-EPMC5705720 | biostudies-literature
UnknownDiscovery of selective activators of PRC2 mutant EED-I363M.
Not available
S-EPMC6484020 | biostudies-literature
UnknownInitial development and testing of an exhaled microRNA detection strategy for lung cancer case-control discrimination.
Not available
S-EPMC10126132 | biostudies-literature
TranscriptomicsNotch1 dose modulates endothelial gene expression
Purpose: To use RNA-Seq analysis of endothelial cell in various Notch1 alllels in order to determine transcrptional differencesas a consequence of Notch dose. Methods: Using a FACS sorting we generated high-throughput RNA-SEQ data of endothelials in various Notch1 alleles during development Results...
ORGANISM(S): Mus musculus 
2015-08-04 | E-GEOD-69276 | biostudies-arrayexpress
UnknownReprogramming CBX8-PRC1 function with a positive allosteric modulator.
Not available
S-EPMC9035045 | biostudies-literature
UnknownHappiness, Meaning, and Psychological Richness.
Not available
S-EPMC9383031 | biostudies-literature
TranscriptomicsIFN-M-NM-3-induced iNOS expression in regulatory macrophages prolongs allograft graft survival in fully immunocompetent recipients.
Mouse monocytes exposed to M-CSF and IFN-M-NM-3 were driven to a suppressor phenotype over a seven day culture period. The resulting regulatory macrophages (M regs) expressed markers distinguishing them from M0-, M1-, and M2-polarised macrophages and monocyte-derived DCs. M regs completely suppresse...
ORGANISM(S): Mus musculus 
2013-12-21 | E-GEOD-32690 | biostudies-arrayexpress
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