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ProteomicsProteomic research on effect of EIF4A1 inhibition in MYC-amplified Group 3 medulloblastoma
As the most life-threatening subtype of pediatric medulloblastoma (MB), MYC-amplified Group 3 (G3) MB lacks effective and selective therapeutics. We tried to indirectly target MYC (oncogenic driver and cancer-dependent molecule) production via inhibiting translational machinery. Through multiple dat...
ORGANISM(S): Homo Sapiens 
2020-10-15 | PXD022014 |
ProteomicsEffects of NMDAR on mouse hippocampal neuron (HT22) proteome expression during hypoxia/reoxygenation injury
Brain tissue is extremely sensitive to hypoxia/reoxygenation (H/R) injury, which can easily cause irreversible damage to neurons. H/R injury could induce neuronal apoptosis through glutamate-mediated excitotoxicity. N-methyl-d-aspartate receptor (NMDAR) is one of the main receptors of excitatory glu...
ORGANISM(S): Mus Musculus 
2022-08-24 | PXD036251 |
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