Gene expression in response to changes in sulfur supply was studied in P. aeruginosa E601, a cystic fibrosis isolate that displays mucin sulfatase activity, and in P. aeruginosa PAO1. A large family of genes was found to be upregulated by sulfate limitation in both isolates, encoding sulfatases and ...
We demonstrate for the first time that the extracellular matrix glycoprotein Tenascin-C regulates the expression of key patterning genes during late embryonic spinal cord development, leading to a timely maturation of gliogenic neural precursor cells. We first show that Tenascin-C is expressed by gl...
The conversion of DHEAS into DHEA by steroid sulfatase (STS) may contribute to sustained intracrine androgen synthesis. Here, we determine the contribution of STS to treatment resistance and explore the potential of targeting STS using novel inhibitors to overcome resistance in prostate cancer.
Deficiency for the enzyme steroid sulfatase (STS) has been associated with postpartum behavioural phenotypes in mice and humans. Here, we compared whole brain gene expression in new mouse mothers acutely treated (two administrations, 48hrs apart) with the STS inhibitor 667-Coumate (10mg/kg p.o.) or ...
