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TranscriptomicsExpression data from TGFBR3 controls and TGFBR3 knockdown of SUM159 3D cultures
The objective of this experiment was to determine global gene expression change in triple negative cell line upon knockdown of TGFBR3. Genotype specific differences in expression profiles have been evaluated using human HuGene1.0-ST affymetrix array. RNA was extracted from SUM159 controls and SUM1...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-54756 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of transmitochondrial cybrids (triple negative breast cancer cells in SUM159 background)
We used a transmitochondrial cybrid (cybrids)-based discovery approach to identify mitochondria-regulated cancer pathways in TN BCa. Cybrids were generated under a moderately metastatic TN BCa cell line SUM159 as the common nuclear background with mitochondria from benign breast epithelium (A1N4) an...
ORGANISM(S): Homo sapiens 
2016-04-14 | E-GEOD-72319 | biostudies-arrayexpress
TranscriptomicsHuman TNBC Cells 72h Treatment with 4.5nM OTSSP167 MELK Inhibitor vs. DMSO Control (SUM159)
Microarray comparing TNBC cells treated for 72 hours with OTSSP167 MELK Inhibitor and control (DMSO) Two-condition arrays: SUM159 cells were treated with either 4.5nM OTSSP167 MELK Inhibitor or 0.045% DMSO for 72h. Two biological replicates, one per array, with a dye swap (technical replicate).
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-71026 | biostudies-arrayexpress
TranscriptomicsHuman TNBC Cells 72h Treatment with 45nM OTSSP167 MELK Inhibitor vs. DMSO Control (SUM159)
Microarray comparing TNBC cells treated for 72 hours with OTSSP167 MELK Inhibitor and control (DMSO) Two-condition arrays: SUM159 cells were treated with either 45nM OTSSP167 MELK Inhibitor or 0.045% DMSO for 72h. Two biological replicates, one per array, with a dye swap (technical replicate).
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-71027 | biostudies-arrayexpress
GenomicsSUM159 cells treated with sudemycin D6 (SD6)
SUM159 cells treated with sudemycin D6 (SD6)
PRJNA686066 | ENA
TranscriptomicsRNA interference uncouples the function of a long noncoding RNA product from that of its transcription [SUM159]
Long noncoding RNAs (lncRNAs) regulate gene expression via their RNA product or through transcriptional interference, yet a strategy to differentiate these two processes is missing. We employed siRNAs to specifically target GNG12-AS1, a lncRNA overlapping the tumour suppressor DIRAS3, transcriptiona...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-60561 | biostudies-arrayexpress
TranscriptomicsGene expression of SUM159-mir100 ALDH+ and ALDH- cells from CTRL or mir100-overexpressing group
Emerging evidence suggest that miRNAs play an essential role in self-renewal and differentiation of normal and malignant stem cells by regulating the expression of key stem cell regulatory genes. Here we demonstrate that mir-100 expression is related to cellular differentiation state with lowest exp...
ORGANISM(S): Homo sapiens 
2014-12-04 | E-GEOD-59361 | biostudies-arrayexpress
TranscriptomicsRNA-seq for ES2, SUM159 or A549 cells treated with GSK-615
GSK-615 was used to treat ES2, SUM159, and A549 cells, and RNA-seq was used to look at how the compound changed gene expression in general. We aimed to predict probable TFs activated with GSK-615 treatment by focusing on the overlapping differentially expressed genes across the three cell lines impa...
ORGANISM(S): Homo sapiens 
2025-01-31 | E-MTAB-14701 | biostudies-arrayexpress
UnknownTR-57 Treatment of SUM159 Cells Induces Mitochondrial Dysfunction without Affecting Membrane Potential.
Not available
S-EPMC10816083 | biostudies-literature
GenomicsTranscriptomic expression of SUM159 cells treated with palbociclib and indisulam
Transcriptomic expression of SUM159 cells treated with palbociclib and indisulam
PRJNA811151 | ENA
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