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TranscriptomicsTCAB1M-oM-
Previous studies indicated TCAB1, also known as WRAP53, had oncogenic feature in a certain extend. However, there is none direct study on the function of TCAB1 in tumorigenesis and development of head and neck cancers. First of all, we verified the function of TCAB1 in head and neck cancers. Knockdo...
ORGANISM(S): Homo sapiens 
2014-06-15 | E-GEOD-54224 | biostudies-arrayexpress
TranscriptomicsLinking immortalization to direct conversion of human fibroblasts to neurons
Direct conversion from fibroblasts to neurons is a potential cell replacement therapy for neurological disorders, and a variety of combinations of transcription factors have been tried. We notice that the efficiency of conversion from aging fibroblasts was much lower than in early stage cells, which...
ORGANISM(S): Homo sapiens 
2012-12-28 | E-GEOD-43175 | biostudies-arrayexpress
TranscriptomicsDirect conversion of fibroblasts to neurons by a new mechanism – p53 regulation
Direct conversion from fibroblast to neuron has recently been successfully induced bypassing the pluripotent state. However, the conversion takes a few months with low percentages of success. Here we found that depletion of p53, which can converted fibroblasts into three major neural lineages: neuro...
ORGANISM(S): Homo sapiens 
2013-04-26 | E-GEOD-46392 | biostudies-arrayexpress
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