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Pulmonary arterial hypertension (PAH) is a fatal disease characterized by a proliferative endothelial cell phenotype, inflammation and pulmonary vascular remodeling. BMPR2 loss-of-function has been linked to pathologic plexiform lesions with obliteration of distal pulmonary arteries distal pulmonary...
ORGANISM(S): Homo sapiens 
The present pre-clinicial study sought to evaluate the novel EGFR inhibitor WSD-0922. We employed flank and orthotopic patient derived xenograft (PDX) models to characterize WSD-0922 and compare its therapeutic efficacy to erlotinib, a potent EGFR inhibitor that failed to provide clinical benefit fo...
ORGANISM(S): Homo sapiens (Human) 
2023-06-21 | PXD032974 | Pride
In the ocean surface layer and cell culture, the polyamine transport protein PotD of SAR11 bacteria is often one of the most abundant proteins detected. Polyamines are organic cations at seawater pH produced by all living organisms and are thought to be an important component of dissolved organic ma...
2021-09-09 | MTBLS3146 | MetaboLights
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